Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C

Table 1 Characteristics of patients without SVR

Stage	0	1	2	3	4	P
n	50	113	68	18	38
Age (yr)	46.2 ± 17.9	55.9 ± 12.8	59.7 ± 9.9	57.2 ± 11.6	65.0 ± 10.2	< 0.001
M/F	25/25	54/59	19/49	7/11	21/17	0.031
HCV serotype
1		48	34	7	17
2		23	12	1	3
ND		42	22	10	18	NS
Histological -grading
Minimal		57	11		2
Mild		50	38	8	6
Moderate		6	19	10	6
Severe					1
ND					23

Results for age are given as mean ± SD deviation. SVR: sustained viral response; ND: not done.

Table 2 Characteristics of patients with SVR

Stage	1	2	3	4	P
n	9	8	3	5
Age (yr)	60.0 ± 8.6	60.2 ± 10.3	66.0 ± 6.1	58.5 ± 8.1	NS
M/F	5/4	3/4	2/1	2/3	NS
Serotype
1	4	3	1	2
2	3	4	2	2
ND	2	1		1	NS
Histological -grading
Minimal	1			2
Mild	3	4	1	1
Moderate	4	3	2	1
Severe	1	1	0	1
Period from liver	2141	981	2187	2240
biopsy (d)	(626-5667)	(282-2285)	(1191-2946)	(970-3074)	NS

Results for age are given as mean ± SD. SVR: sustained viral response; ND: not done.

Table 3 Results of biochemical examination of patients

Stage	1	2	3	4	P
n	113	68	18	38
Platelet (× 104μL)	18.0 ± 8.0	13.9 ± 6.6	12.1 ± 5.7	9.9 ± 5.6	< 0.001
AST (IU)	47.3 ± 31.9	51.6 ± 27.2	63.8 ± 33.4	95.9 ± 142.2	0.001
ALT (IU)	60.9 ± 59.3	61.0 ± 40.5	75.8 ± 51.0	86.8 ± 135.7	0.023
ALB (g/dL)	3.9 ± 1.0	3.6 ± 1.3	3.8 ± 1.0	3.3 ± 1.1	0.036
HA (ng/mL)1	56.7 ± 65.8	89.2 ± 112.0	113.8 ± 125.8	509.3 ± 404.7	< 0.001
IV collagen (ng/mL)2	121.0 ± 57.5	149.9 ± 67.9	176.8 ± 129.2	229.7 ± 108.8	0.020
IV collagen 7S (ng/mL)2	5.5 ± 1.8	6.0 ± 1.6	8.9 ± 2.9	8.0 ± 2.1	0.001
P-III-P (U/mL)2	0.79 ± 0.19	0.88 ± 0.30	1.23 ± 0.60	1.02 ± 0.29	0.023

Results are given as mean ± SD.

¹HA was measured in 57 patients;

²IVcollagen, IVcollagen 7S, and P-III-P were measured in 52 patients. AST: asparate aminotransferase; ALT: alanine aminotransferase; ALB: albumin; HA: hyaluronic acid.