Evaluation of intraoperative radiotherapy for gastric carcinoma with D2 and D3 surgical resection

Table 1 Clinical data of gastric carcinomas in different stages classified by intraoperative radiotherapy (IORT) and operation alone

Groups	Staging	n	Location of tumor n (%)			Operation method n (%)
			Antrum	Body	Cardiac	TS	D2	D3	DG	PG	TG
IORT
	I	13	8 (62)	2 (15)	3 (23)	0 (0)	9 (69.3)	4 (30.7)	10 (76.9)	3 (23.1)	0 (0)
	II	17	12 (70.6)	2 (11.8)	3 (17.6)	0 (0)	6 (35.3)	11 (64.7)	13 (76.5)	3 (17.6)	1 (5.9)
	III	48	25 (52.1)	6 (12.5)	8 (16.7)	9 (18.7)	9 (18.8)	39 (81.3)	30 (62.5)	5 (10.4)	13 (27.1)
	IV	28	13 (46.4)	2 (7.1)	5 (17.9)	8 (28.6)	3 (10.7)	25 (89.3)	14 (50)	6 (21.4)	8 (28.6)
Operation
	I	70	50 (71.4)	16 (22.9)	4 (5.7)	0 (0)	50 (71.4)	20 (28.6)	66 (94.3)	4 (5.7)	2 (2.8)
	II	67	49 (73.1)	5 (7.5)	13 (19.4)	0 (0)	31 (46.3)	36 (53.7)	54 (80.6)	11 (16.4)	2 (3.0)
	III	244	164 (67.2)	37 (15.2)	28 (11.5)	15 (6.1)	110 (45.1)	134 (54.9)	201 (82.4)	28 (11.5)	15 (6.1)
	IV	60	36 (60)	10 (16.7)	6 (10)	8 (13.3)	8 (13.3)	52 (86.7)	42 (70)	4 (6.7)	14 (23.3)

TS: Total stomach; D2: Lymph node 2 dissection; D3: Lymph node 3 dissection; DG: Distal gastrectomy; PG: Proximal gastrectomy; TG: Total gastrectomy.

Table 2 The 5-yr survival rate of patients with operation combined with intraoperative radiotherapy (IORT)

Groups	n	StageI	Stage II	Stage III	Stage IV
IORT	106	13/13 (100%)	17/17 (100%)	29/48 (60.4%)	4/28 (14.3%)
Operation	441	65/70 (92.8%)	54/67 (80.6%)	110/22 (45.1%)	6/6 (10.0%)
P		> 0.10	< 0.001	< 0.005	> 0.05

Table 3 The 5-yr survival rate of patients with operation combined with intraoperative radiotherapy (IORT) in stage III

Groups	n	D2 resection						D3 resection
		n	1 yr	2 yr	3 yr	4 yr	5 yr	n	1 yr	2 yr	3 yr	4 yr	5 yr
IORT	48	9	100%	100%	87.5%	87.5%	60%	39	100%	100%	93.1%	85.5%	61%
Operation	244	114	81.6%	70.4%	52.3%	43.3%	35.7%	128	92.1%	85%	66.5%	62.2%	56.3%
P			< 0.05	< 0.001	< 0.001	< 0.001	< 0.005		> 0.50	> 0.10	< 0.001	< 0.005	> 0.05