Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice

Table 1 Preventive effect on colon injury of oxycoccusan OP administered orally two days before infusion of acetic acid into the rectum of mice (means ± SD)

Pretreatment	Macroscopic damage score	Total square of injury, %
Vehicle-treated (Colitis)	2.7 ± 0.8	21 ± 7
Oxycoccusan OP
25 mg/kg	2.0 ± 0.4	17 ± 9
50 mg/kg	2.0 ± 0.8	20 ± 9
100 mg/kg	1.1 ± 0.4b	10 ± 2b
Prednisolone 5 mg/kg	1.3 ± 0.7b	8 ± 3b
Apple pectin 100 mg/kg	2.6 ± 0.7	23 ± 9

^bP < 0.01 vs the vehicle-treated colitis group (‘Colitis’). n = 7.

Table 2 Preventive effects on colonic MDA levels of oxycoccusan OP administered orally two days before infusion of acetic acid into the rectum of mice (means ± SD)

Pretreatment	nmol/mg of protein
Healthy	3.6 ± 0.8
Vehicle-treated (Colitis)	5.1 ± 0.8
Oxycoccusan OP 100 mg/kg	3.6 ± 0.7b
Apple pectin 100 mg/kg	4.2 ± 1.4

^bP < 0.01 vs vehicle-treated colitis group (‘Colitis’). n = 7.