Review
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2006; 12(4): 539-545
Published online Jan 28, 2006. doi: 10.3748/wjg.v12.i4.539
Table 1 Important roles of PAF in pathogenesis of AP
Main pathogenesis of APImportant roles of PAF
Excessive leukocyte stimulationTo facilitate adhesion, chemotaxis and degranulation and to mediate the production of inflammatory mediators of leukocytes, and to delay PMN apoptosis
Microcirculatory disorderTo modulate indirectly/directly microvascular permeability
Gut endothelial barrier dysfunctionTo upregulate adhesion molecules, intercellular signals and leukocyte–endothelial cell interactions
Bacterial translocationTo depend on its ability to induce gut endothelial barrier dysfunction
Acinar cell necrosis and apoptosisTo mediate neutrophil chemotaxis and delay neutrophil apoptosis in the pancreas, but neutrophils convert acinar cells undergoing apoptosis into necrotic cells