Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis

Table 1 Characteristics of patients with ulcerative colitis

Characteristic	UC (n = 131)
Age of onset (yr)	36.8 ± 15.3
Colitis duration (yr)	8.8 ± 7.7
Extension
Proctitis	22 (16.8%)
Left-sided	59 (45.0%)
Pancolitis	50 (38.2%)
Type of clinical course
First episode	14 (10.7%)
Chronic relapse	79 (60.3%)
Chronic persistent	38 (29.0%)
Severity
Mild	40 (30.5%)
Moderate	61 (46.6%)
Severe	30 (22.9%)

Table 2 Allele frequency and genotype distribution of LPL polymorphism in UC patients and controls

	Allele frequency		Genotype (%)		OR (95% CI)
Ser447stop	C	G	CC	CG+GG
UC (n = 131)	0.92	0.08	111 (84.7)	19 + 1 (15.3)	1.49
Control (n = 104)	0.88	0.12	82 (78.8)	19 + 3 (21.2)	(0.76-2.91)
HindIII	H+	H-	H+/+	H+/- + H-/-
UC (n = 130)	0.80	0.20	86 (66.1)	37 + 7 (33.9)	1.28
Control (n = 106)	0.74	0.26	64 (60.4)	28 + 14 (39.6)	(0.75-2.18)
PvuII	P+	P-	P+/+	P+/- + P-/-
UC (n = 131)	0.70	0.30	65 (49.6)	53 + 13 (50.4)	1.44
Control (n = 106)	0.64	0.36	43 (40.6)	50 + 13 (59.4)	(0.86-2.42)

Table 3 Age of onset of UC patients and LPL polymorphisms

Age of onset (yr)	Genotype		OR (95% CI)
Ser447stop	C/G+G/G	C/C
< 20 (n = 15)	5	10	3.13
≥ 20 (n = 116)	16	100	(0.94-10.33)
HindIII	H+/- + H-/-	H+/+
< 20 (n = 15)	8	7	2.31
≥ 20 (n = 115)	36	79	(0.84-7.45)
PvuII	P+/- + P-/-	P+/+
< 20 (n = 15)	9	6	1.55
≥ 20 (n = 116)	57	59	(0.52-4.64)

Table 4 Triglyceride levels of UC patients and LPL polymorphisms

Triglycerides(mg/dL)	Genotype		OR (95%CI)
Ser447stop	C/C	C/G + G/G
≥ 150 (n = 20)	19	1	4.93 (0.61-40.03)
< 150 (n = 68)	54	14
HindIII	H+/+	H+/- + H-/-
≥ 150 (n = 20)	18b	2	6.46 (1.39-30.12)
< 150 (n = 67)	39	28
PvuII	P+/+	P+/- + P-/-
≥ 150 (n = 20)	13a	7	3.0 (1.06-8.50)
< 150 (n = 68)	26	42

^aP < 0.05 vs P^+/- + P^-/- group;

^bP < 0.01 vs H^+/- + H^-/- group.