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Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 14, 2006; 12(38): 6198-6202
Published online Oct 14, 2006. doi: 10.3748/wjg.v12.i38.6198
Table 1 Clinical characteristics of patients with liver steatosis
Clinical characteristicGrade of steatosis (% of steatosis hepatocytes)
< 33%(groupI)33%-66%(group II)> 66%(group III)
n243525
BMI28 kg/m230 kg/m232 kg/m2
Cholesterol (mmol/L) Trigliceryde (mmol/L)5.50 ± 0.75 2.60 ± 1.275.99 ± 1.29 2.78 ± 1.446.80 ± 2.30 3.16 ± 1.11
Bilirubina (µmol/L)11.97 ± 5.13bd17.1 ± 6.8427.36 ± 20.52
ALT (μkat/L)0.84 ± 0.35bd1.70 ± 1.121.67 ± 0.38
AST (μkat/L)0.60 ± 0.33bd1.19 ± 0.501.87 ± 1.80
ALP (μkat/L)1.12 ± 0.27bd1.72 ± 0.452.10 ± 0.92
GGT (μkat/L)0.75 ± 0.33bd2.61 ± 3.42d5.06 ± 4.34
Total protein (g/L)7.4 ± 04d7.0 ± 0.5d6.4 ± 0.5
Albumin (g/L)4.5 ± 1.2d4.0 ± 0.2d3.4 ± 0.7
Table 2 Percentage of hepatocytes containing pro- and antiapoptotic proteins depending on the stage of liver steatosis (mean ± SD, %)
TotalGroupIGroup IIGroup III
Bax NSH 159 ± 2166 ± 1552 ± 2757 ± 19
Bax SH 268 ± 2371 ± 2163 ± 2867 ± 18
p53 NSH 124 ± 1218 ± 14d21 ± 9 d35 ± 9
p53 SH 222 ± 1714 ± 18bd20 ± 13d33 ± 14
Bcl2 NSH 155 ± 2677 ± 21bd46 ± 2049 ± 27
Bcl2 SH 244 ± 2752 ± 3742 ± 2041 ± 24
Table 3 Correlation of biochemical degree of liver damage and expression of pro- and anti-apoptotic proteins in hepatocytes with the stage of liver steatosis
r
ALT  0.6b
AST  0.37b
ALP  0.55b
GGT  0.53b
Total protein-0.54b
Albumines-0.34b
Bax NSH1NS3
Bax SH2NS3
p53 NSH1  0.49b
p53 SH2  0.54b
Bcl2 NSH1-0.43b
Bcl2 SH2NS3