Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 14, 2006; 12(38): 6193-6197
Published online Oct 14, 2006. doi: 10.3748/wjg.v12.i38.6193
Table 1 Clinical characteristics of patients with liver cirrhosis
CharacteristicChild-pugh BChild-pugh C
Encephalopathy (n)210
Ascites (n)919
Median bilirubin (range) (mg/L)34 (9–78)69 (22–139)
Median albumin (range) (g/L)29 (22–33)22 (19–29)
Median prothrombin time (range) (s)19 (17.2–23.3)23 (18.2–26.8)
Table 2 β2-integrin expression on peripheral blood leukocytes and sICAM-1 and TNF-α serum concentrations in liver cirrhosis (stages B and C) and in healthy subjects
LeukocytesReceptoresHealthy subjects(n = 20)Liver
cirrhosis
Stage B(n = 21)Stage C(n = 19)
CD14 (%)26.2 ± 2.326.1 ± 6.326.8 ± 3.9
MonocytesMIF12.9 ± 1.58.7 ± 6.98.1 ± 6.1
CD11a (%)99.9 ± 0.0999.9 ± 0.0899.9 ± 0.8
MIF114.8 ± 2.415.1 ± 1.8a16.3 ± 1.7b
CD11b (%)99.8 ± 0.0899.5 ± 0.799.8 ± 0.2
MIF118.4 ± 4.618.7 ± 4.8a22.2 ± 4.4a
CD11c (%)99.5 ± 0.597.5 ± 4.596.6 ± 7.0
MIF16.5 ± 1.37.0 ± 1.57.4 ± 2.1
CD49d (%)63.8 ± 14.766.9 ± 22.566.2 ± 21.2
MIF11.39 ± 0.431.85 ± 0.721.52 ± 0.68
GranulocytesCD11a (%)99.3 ± 0.598.0 ± 4.894.7 ± 0.5
MIF14.4 ± 0.44.3 ± 0.54.4 ± 0.7
CD11b (%)99.5 ± 1.199.5 ± 0.798.6 ± 2.7
MIF110.5 ± 2.410.0 ± 2.8a12.1 ± 2.6
CD11c (%)87.0 ± 5.080.8 ± 11.471.9 ± 12.4
MIF12.8 ± 0.42.7 ± 0.73.0 ± 0.9
CD49d (%)4.4 ± 2.44.6 ± 3.06.3 ± 3.9
MIF10.13 ± 0.010.17 ± 0.05b0.17 ± 0.03b
LymphocytesCD11a (%)98.1 ± 0.897.2 ± 1.797.6 ± 1.3
MIF18.0 ± 1.29.7 ± 1.6b9.9 ± 2.0b
CD11b (%)23.7 ± 5.324.5 ± 5.224.0 ± 8.0
MIF10.56 ± 0.120.61 ± 0.18a0.75 ± 0.24
CD11c (%)25.2 ± 6.623.2 ± 5.629.4 ± 7.3
MIF10.77 ± 0.120.91 ± 0.331.0 ± 0.25b
CD49d (%)31.2 ± 12.537.9 ± 12.138.8 ± 11.8
MIF10.48 ± 0.120.68 ± 0.34b0.63 ± 0.18b
sICAM-1 (μg/L)254 ± 74839 ± 34b957 ± 328b
TNFα (μg/L)1.58 ± 0.222.89 ± 1.34b2.98 ± 1.42b
Table 3 The correlation of β2-integrin expression on leukocytes and sICAM level in blood sera from liver cirrhosis (stages B and C)
CD11aCD11bCD11cCD49d
Monocytes
Monocytes CD11aH1: r = 0.6, P < 0.01B2: r = 0.39, P < 0.05 C3: r = 0.56, P < 0.01 H1: r = 0.73, P < 0.01NS4
Granulocytes
NS4NS4NS4NS4
Lymphocytes
B2: r = 0.56, P < 0.01NS4NS4NS4
GranulocytesMonocytes
CD11aNS4NS4C3: r = 0.47, P < 0.04NS4
Granulocyte
C3: r = 0.42, P < 0.01C3: r = 0.53, P < 0.01
H1: r = 0.54, P < 0.05
Lymphocytes
NS4NS4NS4NS4
LymphocytesMonocytes
CD11aNS4NS4NS4NS4
Granulocytes
NS4NS4NS4NS4
Lymphocytes
C3: r = 0.51, P < 0.02NS4C3: r = 0.51, P < 0.02