Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2006; 12(37): 5932-5940
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.5932
Table 1 False negative in antigen positive neoplasms,comparative features of microsatellite unstable sporadic adenocarcinoma and hnpcc colon carcinomas
MSI-H sporadic adenocarcinomasHNPCC adenocarcinomas
Patient ageOlderYounger
Number of tumorsSingleSingle/Multiple (synchronic/metachronic)
Colonic distributionRight colonRight colon
Histological cluesPoorly differentiated, medullary type Crohn-like inflammationPoorly differentiated, medullary type Crohn-like inflammation
Mechanism of MMR deficiencyMLH1 promoter hypermethylationInactivating germline mutation of MMR proteins
Tumor prognosisBetter than MSI-L/MSS sporadic adenocaBetter than MSI-L/MSS sporadic adenoca