Clinical Research
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 28, 2006; 12(36): 5846-5852
Published online Sep 28, 2006. doi: 10.3748/wjg.v12.i36.5846
Table 1 Plasma 8-isoprostane in three groups with different drinking habits (means ± SD)
Plasma 8-isoprostane (ng/L)
Group III vsGroup IGroup III vsGroup I
Group IGroup IIGroup III
Total20.3 ± 6.1 (n = 64)20.9 ± 5.7 (n = 56)26.6 ± 9.5 (n = 37)t = 4.059 P < 0.0001 (CI: 3.222-9.387)t = 3.587 P < 0.001 (CI: 2.523-8.783)
Male22.5 ± 6.3 (n = 32)21.1 ± 4.9 (n = 31)23.7 ± 8.0 (n = 20)t = 0.589 N.S. (CI: -2.832-5.181)t = 1.464 N.S. (CI: -0.981-6.252)
Female18.1 ± 5.0 (n = 32)20.8 ± 6.6 (n = 25)30.0 ± 10.3 (n = 17)t = 5.494 P < 0.0001 (CI: 7.572-16.321)t = 3.542 P < 0.005 (CI: 3.954-14.466)
Table 2 Spearman correlation coefficients between biochemical parameters (n = 157)
TCTGHDL-CLDL-CapoA IapoBLp(a)ASTALTγ-GTP8-isoprostane
Age0.3730.1220.0120.3240.0880.3810.0550.1160.1390.436-0.062
TC-0.3560.2720.8180.233 0.7990.2110.091 0.1230.273-0.042
TG---0.2150.446-0.037 0.5650.1280.182 0.2470.325-0.020
HDL-C----0.2090.849-0.242-0.001-0.068-0.250-0.059-0.101
LDL-C-----0.169 0.9650.264 0.122 0.2480.235 0.080
apoA I------0.155-0.038 0.022-0.1210.083-0.118
apoB------0.295 0.171 0.2960.335 0.069
Lp(a)------- 0.057 0.060 -0.029 0.124
AST-------- 0.8970.411-0.034
ALT---------0.509 0.002
γ-GTP-----------0.085
Table 3 Plasma 8-isoprostane analyzed by ALDH2 genotype in three groups with different drinking habits (means ± SD)
Plasma 8-isoprostane (ng/L)
Group III vsGroup IGroup III vsGroup I
Group IGroup IIGroup III
ALDH2*1/1Male20.2 ± 5.819.8 ± 5.022.8 ± 5.4t = 1.165, N.S. (CI: -1.988-7.137)t = 1.664, N.S. (CI: -0.684-6.758)
Female19.0 ± 5.821.6 ± 6.626.9 ± 7.7t = 2.754, P < 0.05 (CI: 1.926-13.808)t = 1.897, N.S. (CI: -0.447-10.887)
Total19.6 ± 5.7 (n = 22)20.6 ± 5.8 (n = 33)24.6 ± 6.7 (n = 27)t = 2.776, P < 0.01 (CI: 1.375-8.616)t = 2.471, P < 0.05 (CI: 0.757-7.219)
ALDH2*1/2Male23.7 ± 7.5 (n = 11)22.6 ± 4.4 (n = 12)28.5 ± 14.8 (n = 4)t = 0.834, N.S. (CI: -7.517-16.976)t = 1.281, N.S. (CI: -3.934-15.600)
Female16.0 ± 4.0 (n = 15)19.9 ± 7.4 (n = 8)41.2 ± 12.3 (n =3)t = 6.930, P < 0.0001 (CI: 17.459-32.848)t = 3.622, P < 0.01 (CI: 8.017-34.683)
Total19.3 ± 6.8 (n = 26)21.5 ± 5.8 (n = 20)33.9 ± 14.4 (n = 7)t = 3.898, P < 0.001 (CI: 6.973-22.276)t = 3.267, P < 0.005 (CI: 4.586-20.221)
ALDH2*2/2Male22.2 ± 5.5 (n = 6)----
Female21.8 ± 2.0 (n = 3)----
Total22.0 ± 4.7 (n = 9)----