Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats

Table 1 Comparative biochemical measurements at the two week of the study (mean ± SD)

Groups	Biochemical parameters
	ALP(IU/L)	GGT(IU/L)	TB(mg/dL)	AST(IU /L)	ALT(IU/L)
Sham-control	177 ± 20	1.9 ± 0.3	0.3 ± 0.2	117 ± 3.3	55 ± 10
Untreated	386 ± 44a	49 ± 10a	11 ± 1.3a	1378 ± 256a	258 ± 62a
Low-dose dexa	297 ± 78c	20 ± 2.3c	8 ± 0.8c	1037 ± 215c	198 ± 39c
High-dose dexa	300 ± 60e	19 ± 2e	8 ± 1.1e	963 ± 139e	150 ± 43e

ALP: Alkaline phosphatase; GGT: γ-glutamyltranspeptidase; TB: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.

^aP < 0.05 vs sham-control;

^cP < 0.05 vs untreated;

^eP < 0.05 vs untreated.

Table 2 Comparative SOD, CAT and GSH-Px measurements at the two week of the study (mean ± SD)

Groups	SOD	CAT	GSH-Px
	(IU/L)	(IU/L)	(mg/dL)
Sham-control	16 ± 2.5	5.1 ± 0.9	430 ± 31
Untreated	6.9 ± 0.9a	0.8 ± 0.1a	142 ± 13a
Low-dose dexa	10.6 ± 1.2c	2.7 ± 0.6c	254 ± 15c
High-dose dexa	10.7 ± 0.9e	2.6 ± 0.6e	255 ± 19e

SOD: Superoxide dismutase; CAT: Catalase; GSH-Px: Glutathione peroxidase.

^aP < 0.05 vs sham-control;

^cP < 0.05 vs untreated;

^eP < 0.05 vs untreated.