Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients

Table 1 Haplotype frequencies at five positions of the SPINK1 gene from 90 individuals (180 chromosomes) as estimated by EM-algorithm

Haplotype	IVS2-352 A/G	IVS3-1643 G/C	IVS3-1568 C/A	IVS3-476 T/G	IVS3-321 C/T	nhplt1	Haplotype frequency2
1	A	G	C	T	C	61	0.338889
2	G	G	C	T	C	35	0.194444
3	A	G	C	T	T	4	0.022222
4	A	G	A	T	C	2	0.011111
5	G	G	C	T	T	6	0.033333
6	G	G	C	G	C	2	0.011111
7	G	G	A	T	C	7	0.038889
8	A	G	A	T	T	1	0.0055556
9	A	C	A	T	C	2	0.011111
10	G	G	A	T	T	28	0.155556
11	G	G	A	G	C	1	0.0055556
12	G	C	A	T	C	4	0.022222
13	G	G	A	G	T	1	0.0055556
14	G	C	A	T	T	25	0.138889
15	G	C	A	G	T	1	0.0055556
Total	70/110	148/32	108/72	175/5	114/66	180	1.0

¹ Estimated number of haplotypes.

² The remaining 17 possible haplotypes could not be found in any individual.