Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer

Table 1 Tumor parameters in colorectal cancer patients

Parameters	Patients (n)
Tumor location
Rectum	70
Left colon	104
Right colon	48
Tumor size
≤ 3 cm	69
> 3 cm	153
Growth pattern
Ulcerative	89
Protruding	133
Differentiation
Good	43
Moderate	147
Poor	32
TNM stage
I	32
II	96
III	68
	26

Table 2 Allele and genotype frequencies of the polymorphisms under investigation in CRC patients and healthy controls

			Alleles					Genotypes
IL-6
	C	G	G allele frequencies (%)	P; OR (95% CI)	CC	CG	GG	GG genotype frequencies (%)	P; OR (95% CI)
CRC	146	298	67.1	< 0.0001; 1.77 (1.34-2.34)	35	76	111	50	< 0.0005; 2.10 (1.40-3.16)
Controls	186	214	53.5		50	86	64	32
IL-8
	A	T	T allele frequencies (%)	P; OR (95% CI)	AA	AT	TT	TT genotype frequencies (%)	P; OR (95% CI)
CRC	186	258	58.11	0.467; 1.10	40	106	76	34.23	0.256; 0.77
Controls	174	218	54.5	(0.84-1.45)	42	90	64	32	(0.49-1.20)
TNFα
	G	A	Α allele frequencies (%)	P; OR (95% CI)	GG	GA	AA	ΑΑ genotype frequencies (%)	P; OR (95% CI)
CRC	360	84	18.92	0.265; 1.18	152	56	14	6.31	0.586; 1.28
Controls	336	64	16	(0.83-1.68)	146	44	10	5	(0.53-3.1)
ICAM-1 R241G
	G	R	R allele frequencies (%)	P; OR (95% CI)	GG	GR	RR	RR genotype frequencies (%)	P; OR (95% CI)
CRC	362	82	18.47	0.002; 1.83	144	74	4	1.8	0.652; 1.50
Controls	356	44	11	(1.23-2.72)	158	40	2	1	(0.26-8.7)
ICAM-1 K469E
	E	K	K allele frequencies (%)	P; OR (95% CI)	EE	EK	KK	KK genotype frequencies (%)	P; OR (95% CI)
CRC	236	208	46.85	0.031; 1.35	70	96	56	25.22	0.221; 1.33
Controls	242	158	39.5	(1.03-1.77)	77	88	35	17.5	(0.83-2.12)
PPARγ
	C	G	C allele frequencies (%)	P; OR (95% CI)	CC	CG	GG	CC genotype frequencies (%)	P; OR (95% CI)
CRC	376	68	84.7	0.001; 1.78	164	48	10	73.8	< 0.001; 2.01
Controls	306	94	76.5	(1.25-2.49)	118	70	12	59	(1.32-3.09)