Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma

Table 1 Histopathological alterations of hepatocytes at different stages of rat hepatomas induced with 2-FAA

Group	n	Pathological feature (HE staining)
		Degeneration Precancerosis Cancerization
Control	6	0	0	0
2th	6	6	0	0
4th	6	3	3	0
6th	6	0	5	1
8th	6	0	4	2
10th	6	0	1	5
12th wk	51	0	0	5
Total	41	9	13	13

¹ One rat died during the experimental process; 2-FAA: 2-fluoenylacetamide.

Table 2 Diagnostic values of different telomerase levels in peripheral blood mononuclear cells for hepatocellular carcinoma

Group	n	Positive (%)
		△A>0.2	△A>0.4	△A>0.6
HCC	135	115 (85.2)	101 (74.8)	81 (60.0)
Liver cirrhosis	37	17 (45.9)	6 (16.2)b	2 (5.4)b
Chronic hepatitis	80	20 (25.0)b	8 (10)b	0 (0)b
Normal control	70	11 (15.7)b	0 (0)b	0 (0)b

^bP < 0.01 vs the HCC group.

Table 3 Assessment of the diagnostic values of different telomerase levels

			Predictive value
Telomerase	Sen (%)	Spe (%)	Pos (%)	Neg (%)	Acc (%)
△A > 0.2	85.2	68.4	75.7	80.0	77.4
△A > 0.4	74.8	88.0	87.8	75.2	81.0
△A > 0.6	60.0	98.3	97.6	68.0	77.8

Sen: Sensitivity; Spe: Specificity; Pos: Positive; Neg: Negative; Acc: Accuracy.