Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma

Table 1 Telomerase activity and hTERT expression in four different groups

Group	n	Telomerase n (%)	hTERT n (%)
Colorectal carcinoma	30	25 (83.33)a	23 (76.67)a
Adjacent peritumoral tissues	30	4 (13.33)	5 (16.67)
Adenomatoid polyp	20	2 (10.00)	2 (10.00)
Normal mucosa	30	1 (3.33)	1 (3.33)

^aP<0.05 (χ²=59.58, χ²=49.23) vs adjacent peritumoral tissues, adenomatoid polyp and normal mucosa.

Table 2 Relation between telomerase activity and hTERT expression and clinical pathologic factors of colorectal carcinoma

Group	n	Telomerase (%)	hTRET (%)
Dukes’ A	0	0	0
Dukes’ B	2	1/2a	1/2a
Dukes’ C	24	83.33 (20/24)	83.33 (20/24)
Dukes’ D	4	4/4a	2/4a
High differentiation	5	2/5a	3/5a
Moderate differentiation	8	6/8a	5/8a
Poor differentiation	17	100.00 (17/17)	88.24 (15/17)
With lymphatic metastasis	10	80.00 (8/10)b	70.00 (7/10)b
Without lymphatic metastasis	20	0.00 (0/20)	5.00 (1/20)

^aindicates cases less than 10 not included in the percentage;

^bP<0.01 vs the group without lymphatic metastasis

Table 3 Correlation between telomerase activity and hTERT expression

Telomerase	hTERT
	n	+	--	P
+	25	20	5	<0.05
--	5	3	2