Pharmacodynamic and kinetic effect of rabeprazole on serum gastrin level in relation to CYP2C19 polymorphism in Chinese Hans

Table 1 AUC of RPZ 20 mg after a single and repeated doses

	AUCa (μg/L per h) d 1	AUCa (μg/L per h) d 8
homEM	1150.24 ± 327.34	1445.28 ± 205.16
hetEM	1539.42 ± 190.29	1640.91 ± 249.51
PM	2015.38 ± 588.88	2495.61 ± 738.61

^aP < 0.05 homEM vs PM.

Table 2 Median (interquartile range) 24 h pH after a single and repeated doses of RPZ 20 mg

	HomEM	HetEM	PM
D 1	3.82	4.36	6.09
	(2.1-5.2 )	( 2.0-6.1)	( 4.9-6.8)
D 8	4.52	4.37	5.67
	( 3.0-5.5)	(2.9-6.0 )	(4.8-6.5 )
D 1/D 8 (%)	84.5	99.8	107.4

Table 3 Serum gastrin level with reference to CYP2C19 polymorphism

	HomEM		HetEM		PM
	D 1	D 8	D 1	D 8	D 1	D 8
Gastrin AUC (pg/mL per h)a	812.03 ± 147.02	1169.98 ± 333.70	964.08 ± 377.20	1771.38 ± 1024.90	1181.06 ±420.70	1897.45 ± 1359.59

^aP < 0.05, AUC on d 1 vs AUC on d 8.