Influence of zinc sulfate intake on acute ethanol-induced liver injury in rats

Table 1 Blood glutathione and serum enzymes (mean ± SD)

Group	n	GSH (mg %)	Pt-test	ALP (U/L)	Pt-test	AST(U/L)	Pt-test
Control	8	52.59 ± 2.44		101.12 ± 1.64		122.55 ± 2.61
			0.009
					0.0001		0.001
Control + Zinc sulfate	8	46.65 ± 4.90		73.91 ± 6.28		106.03 ± 8.97
Ethanol	14	35.09 ± 2.31b		110.02 ± 2.88b		133.00 ± 4.82b
			0.005		0.0001		0.0001
Ethanol + Zinc sulfate	11	38.39 ± 6.18		84.80 ± 7.09		112.56 ± 8.18
PANOVA		0.0001		0.0001		0.0001

^bP_t-test = 0.0001 vs Control.

Table 2   Effects of zinc sulfate on the levels of lipid peroxidation and glutathione in the liver (Mean ± SD)

Group	n	GSHnmol GSH/mg	Pt-test	LPOnmol MDA/mg	Pt-test
		protein		protein
Control	8	16.64 ± 1.24		0.52 ± 0.12
			0.589		0.065
Control + Zinc sulfate	8	15.84 ± 3.87		0.69 ± 0.06
Ethanol	14	12.23 ± 2.92b		0.93 ± 0.06b
			0.0001		0.001
Ethanol + Zinc sulfate	11	20.74 ± 5.11		0.51 ± 0.10
PANOVA		0.0001		0.0001

^bP_t-test = 0.0001 vs Control.