Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population

Table 1 Relationship between hereditary instability of BRCA1 gene at locus D17S855 and clinicopathological parameters of gastric cancer

Clinicopatho- logical parameters	Case (n)	MSI positive rates (%)	LOH positive rates (%)	BRCA1 positive rates (%)	BRCA1 expression (PU Mean±S)
Histology	37	7 (18.92%)	7 (18.92%)	14 (37.84%)	33.56 ± 2.23
Tubuladenoma	30	6 (20.00%)	6 (20.00%)	12 (40.00%)	32.87 ± 2.93
High
differentiation	9	4 (44.44%) 1 (7.69%)	1 (11.11%)	7 (77.78%)a	34.03 ± 1.79
Middle
differentiation	13	1 (12 .50 %)	1 (7.69%)	4 (30.77%)	33.49 ± 2.34
Low
differentiation	8	1 (14.29%)	4 (50.00%)	1 (12.50%)	33.58 ± 1.67
Mucoadenoma	7		1 (14.29%)	2 (28.57%)	32.87 ± 2.59
Lymph metastasis
No	17	5 (29.41%)	1 (5.88%)	9 (52.94%)	34.75 ± 1.78
Yes	20	2 (10.00%)	6 (30.00%)	5 (25.00%)	33.14 ± 2.14
TNM staging
Stage I + II	19	6 (31.58%)	1 (5.26%)	11 (57.89%)	33.88 ± 2.38
Stage III + IV	18	1 (5.56%)a	6 (33.33%)a	3 (16.67%)a	33.23 ± 2.34

^aP < 0.05.

Table 2 Relationship between MSI, LOH of BRCA1 gene at locus D17S855 and BRCA1 protein expression

Grouping	Cases	BRCA1 proteinpositive rates	BRCA1 expression(PU Mean±S)
MSI positive group	7	85.71% (6/7)	34.05 ± 1.91
MSI negative group	30	26.67% (8/30) a	32.59 ± 2.23
LOH positive group	7	28.57% (2/7)	32.87 ± 2.35
LOH negative group	30	40.00% (12/30)	34.03 ± 2.66

^aP < 0.05.