Liver Cancer
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 7, 2006; 12(25): 3977-3982
Published online Jul 7, 2006. doi: 10.3748/wjg.v12.i25.3977
Table 1 Effect of αIR3 on growth and proliferation of HepG2 cells treated with various concentrations of αIR3 for 24, 48, 72 and 96 h
GroupCell growth index (GI)
24 h48 h72 h96 h
Control100100100100
0.1 μg/mL100.640103.4133a97.65495.032
0.2 μg/mL104.71698.95294.9961b103.125
0.5 μg/mL99.84098.17591.6341b88.8622a
1.0 μg/mL99.04197.6343a90.774b83.9744b
1.5 μg/mL97.04297.1612b89.8358b79.8077b
2.0 μg/mL96.88395.1335b88.5066b77.2436b
4.0 μg/mL93.3653b92.5313b86.0047b70.5128b
Table 2 Effect of αIR3 on cell cycle and apoptosis of HepG2 cells induced at various concentrations
Cell groupsDistribution of cell cycle (%)
Apoptotic index(%)
G0/G1phaseS phaseG2/M phase
Control44.47 ± 0.416353.17 ± 1.9552.367 ± 2.1224.133 ± 0.3215
0.5 μg/mL61.73 ± 0.3786b28.63 ± 0.5686b9.633 ± 0.35127.833 ± 0.4726b
1.0 μg/mL67.10 ± 0.8185b25.13 ± 0.7506b7.800 ± 0.200016.13 ± 0.3512b
1.5 μg/mL83.70 ± 0.4000b15.63 ± 0.3055b0.6667 ± 0.577421.10 ± 0.5292b
2.0 μg/mL76.87 ± 1.401b23.13 ± 1.401b0 ± 037.73 ± 0.1528b