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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 28, 2006; 12(24): 3803-3809
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3803
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3803
Table 1 Phenotypic expressions, tumor differentiation phenotype and genetic alterations in gastric adenoma and carcinoma n (%)
| Phenotypic | Adenoma | Early | Advanced | Early and |
| expressions,tumor | carcinoma | carcinoma | advanced | |
| differentiation | carcinoma | |||
| phenotype | (n = 48) | (n = 132) | (n = 39) | (n = 171) |
| &genetic | ||||
| Alterations | ||||
| HGM | ||||
| Negative | 43 (89.6) | 49 (37.1)d | 15 (38.5)d | 64 (37.4)d |
| Positive | 5 (10.4) | 83 (62.9)d | 24 (61.5)d | 107 (62.6)d |
| MUC6 | ||||
| Negative | 29 (60.4) | 48 (36.4)b | 13 (33.3)a | 61 (35.7)b |
| Positive | 19 (39.6) | 84 (63.6)b | 26 (66.7)a | 110 (64.3)b |
| MUC2 | ||||
| Negative | 6 (12.5) | 35 (26.5) | 15 (38.5)a | 50 (29.2)a |
| Positive | 42 (87.5) | 97 (73.5) | 24 (61.5)a | 121 (70.8)a |
| CD10 | ||||
| Negative | 16 (33.3) | 100 (75.8)d | 28 (71.8)c | 128 (74.9)d |
| Positive | 32 (66.7) | 32 (24.2)d | 11 (28.2)c | 43 (25.1)d |
| Tumor differentiation phenotype | ||||
| G-phenotype | 2 (4.2) | 30 (22.7)d | 10 (25.6)d | 40 (23.4)d |
| GI-phenotype | 19 (39.6) | 82 (62.1)d | 24 (61.5)d | 106 (62.0)d |
| I-phenotype | 27 (56.3) | 20 (15.2)d | 5 (12.8)d | 25 (14.6)d |
| APC | ||||
| Negative | 29 (60.4) | 110 (83.3)b | 37 (94.9)c | 147 (86.0)d |
| Positive | 19 (39.6) | 22 (16.7)b | 2 (5.1)c | 24 (14.0)d |
| p53 | ||||
| Negative | 46 (95.8) | 99 (75.0)b | 27 (69.2)b | 126 (73.7)b |
| Positive | 2 (4.2) | 33 (25.0)b | 12 (30.8)b | 45 (26.3)b |
| MSI status | ||||
| MSS | 40 (83.3) | 107 (81.1) | 34 (87.2) | 141 (82.5) |
| MSI-L | 4 (8.3) | 16 (12.1) | 2 (5.1) | 18 (10.5) |
| MSI-H | 4 (8.3) | 9 (6.8) | 3 (7.7) | 12 (7.0) |
Table 2 Relationship between expressions of HGM, MUC6, MUC2 and CD10, and genetic alterations in 219 gastric tumors n (%)
| HGM | MUC6 | MUC2 | CD10 | |||||
| Negative(n = 107) | Positive(n = 112) | Negative(n = 90) | Positive(n = 129) | Negative(n = 56) | Positive(n = 163) | Negative(n = 144) | Positive(n = 75) | |
| APC | 35 (32.7) | 8 (7.1)c | 25 (27.8) | 18 (14.0)a | 10 (17.9) | 33 (20.2) | 15 (10.4) | 28 (37.3)c |
| p53 | 21 (19.6) | 26 (23.2) | 19 (21.1) | 28 (21.7) | 10 (17.9) | 37 (22.7) | 28 (19.4) | 19 (25.3) |
| MSI status | ||||||||
| MSI-L | 12 (11.2) | 12 (10.7) | 4 (4.4) | 20 (15.5) | 7 (12.5) | 17 (10.4) | 17 (11.8) | 6 (8.0) |
| MSI-H | 7 (6.5) | 7 (6.3) | 2 (2.2) | 12 (9.3) | 5 (8.9) | 9 (5.5) | 15 (10.4) | 0 (0) |
| Total | 19 (17.8) | 19 (17.0) | 6 (6.7) | 32 (24.8)b | 12 (21.4) | 26 (16.0) | 32 (22.2) | 6 (8.0)a |
- Citation: Yamazaki K, Tajima Y, Makino R, Nishino N, Aoki S, Kato M, Sakamoto M, Morohara K, Kaetsu T, Kusano M. Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations. World J Gastroenterol 2006; 12(24): 3803-3809
- URL: https://www.wjgnet.com/1007-9327/full/v12/i24/3803.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i24.3803