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Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 21, 2006; 12(23): 3636-3644
Published online Jun 21, 2006. doi: 10.3748/wjg.v12.i23.3636
Table 1 Substrates (S), inhibitors (I-) and inducers (I+) of P-glycoprotein (Modified from ref. 9)
DRUGSI-I+DRUGSI-I+
AnticancerAntiviral
Actinomycin DAmprenavir
DaunorubicinIndinavir
Mitomicyn CNelfinavir
MitoxantroneAntibiotics
VinblastineClaritromycin
VincristineErythromycin
AntihypertensiveLevofloxacin
DiltiazemRifampin
LosartanTetracycline
NicardipineAntimycotics
Talinolol±Itraconazole
AntiarrhythmicsKetoconazole
AmiodaroneImmunosup.
DigoxinCyclosporine
QuinidineTacrolimus
VerapamilMethotrexate
GlucocorticoidsAntidepressants
AldosteroneAmitriptyline
CortisolFluoxetine
DexamethasoneNeuroleptics
MethylprednisoloneChlorpromazine
OthersPhenotiazine
ColchicinePhenobarbital
DipyridamoleOpioids
LoperamideMethadone
ProgesteroneMorphine
SpironolactoneAntacids
DomperidoneRanitidine
OndansetronCimetidine
Table 2 Distribution of C3435T alleles and genotypes (cases and controls) in the existing literature
CTCCCTTT
Glas, 2003
UC = 1231111 (45)135 (55)19 (15)73 (60)31 (25)
CD = 135130 (48)140 (52)26 (19)78 (58)31 (23)
IBD = 258241 (47)275 (53)45 (17)151 (59)62 (24)
HC = 265272 (51)258 (49)70 (26)132 (50)63 (24)
Schwab, 2003CTCCCTTT
UCa = 149129 (43)169 (57)26 (17)77 (52)46 (31)
HC = 149154 (52)144 (48)39 (26)76 (51)34 (23)
CD = 126134 (53)118 (47)33 (26)68 (54)25 (20)
HC = 126128 (51)124 (49)35 (28)58 (46)33 (26)
IBD = 275263 (48)287 (52)59 (21)145 (53)71 (26)
HC = 275282 (51)268 (49)74 (27)134 (49)67 (24)
Ho, 2005CTCCCTTT
UCc = 335280 (42)390 (58)61 (18)158 (47)116 (35)
CD = 268252 (47)284 (53)56 (21)140 (52)72 (27)
IBD = 603532 (44)674 (56)117 (19)298 (50)188 (31)
HC = 370354 (48)386 (52)82 (22)190 (51)98 (27)
Palmieri, 2005CTCCCTTT
UC = 468488 (52)448 (48)124 (27)240 (51)104 (22)
CD = 478503 (53)453 (47)125 (26)253 (53)100 (21)
IBD = 946991 (52)901 (48)249 (26)493 (52)204 (22)
HC = 450470 (52)430 (48)115 (26)240 (53)95 (21)
Potocnik, 2004CTCCCTTT
UC = 144134 (47)154 (53)---
CD = 163161 (49)165 (51)---
IBD = 307295 (48)319 (52)
HC = 355376 (53)334 (47)---
Urcelay, 2006
UC = 311317 (51)305 (49)87 (28)143 (46)81 (26)
CDb = 3031369 (61)237 (39)122 (40)125 (41)56 (19)
IBD = 614686 (56)542 (44)209 (34)268 (44)137 (22)
HC = 324344 (53)304 (47)97 (30)150 (46)77 (24)
Table 3 Distribution of G2677T/A alleles and genotypes (cases and controls) in the existing literature
AGTAAGGGTTTGATA
Brant, 2003
IBD_NJa = 2112 (0.5)254 (60.2)166 (39.3)-76 (36)101 (48)32 (15)1 (0.5)1 (0.5)
HC_NJ = 39220 (2.6)411 (52.4)353 (45)-108 (27)183 (47)81 (21)12 (3)8 (2)
IBD_J = 1141 (0.5)143 (62.7)84 (36.8)-41 (36)60 (53)12 (10)1 (1)0
HC_J = 21913 (3)265 (60.5)160 (36.5)-85 (39)89 (41)32 (15)6 (2)7 (3)
Ho, 2005AGTAAGGGTTTGATA
UC = 335-366 (54.6)304 (45.4)-95 (28.3)176 (52.5)64 (19.1)--
CD = 268-283 (52.8)253 (47.2)-75 (27.9)133 (47.8)60 (22.4)--
IBD = 603-649 (53.8)557 (46.2)-170 (28.2)309 (51.2)124 (20.6)--
HC = 370-378 (51.2)362 (49.8)-102 (27.6)174 (47.0)94 (25.4)--
Palmieri, 2005AGTAAGGGTTTGATA
UC = 46823 (2.5)494 (52.8)419 (44.7)1 (0.2)127 (27.1)229 (49.0)90 (19.2)11 (2.4)10 (2.1)
CD = 47815 (1.6)534 (55.9)407 (42.5)0 (0.0)143 (29.9)237 (49.6)83 (17.4)11 (2.3)4 (0.8)
IBD = 94638 (2)1028 (54)826 (44)1 (0.1)270 (29.5)466 (49.2)173 (18.3)22 (2.3)14 (1.5)
HC = 45019 (2.1)500 (55.6)381 (42.3)0 (0.0)126 (28.0)236 (52.4)69 (15.3)12 (2.7)7 (1.6)
Potocnik, 2004A & GT
UC = 144-157 (54)131 (46)------
CD = 163-187 (57)139 (43)------
IBD = 307-344 (56)270 (44)------
HC = 355-424 (59.7)286 (40.3)------
Urcelay, 2006
UC = 3114 (0.7)372 (62.8)216 (36.5)0 (0)118 (39.9)133 (44.9)41 (13.9)3 (1)1 (0.3)
CD = 3036 (0.9)403 (63.2)229 (35.9)0 (0)139 (43.6)122 (38.3)52 (16.3)3 (0.9)3 (0.9)
IBD = 61510 (0.8)775 (63)445 (36.2)0 (0)257 (41.8)255 (41.5)93 (16.1)6 (0.9)4 (0.7)
HC = 3528 (1.1)426 (60.5)270 (38.4)0 (0)140 (39.8)142 (40.3)62 (17.6)4 (1.1)4 (1.1)
Table 4 Summary of ORs and 95% CIs for different outcomes obtained at the meta-analysis
Fixed effects
Random effects
Heterogeneity test
P valueOR (95% CI)P valueOR (95% CI)
C3435TOutcome CD T vs C (6 studies)0.5190.968 (0.878-1.068)0.7220.974 (0.842-1.126)0.09
TT vs CC (5 studies)0.2970.892 (0.720-1.106)0.4720.900 (0.675-1.200)NS
G2677T/AG vs T (4 studies)0.6351.027 (0.920-1.145)0.6351.027 (0.920-1.145)NS
GG vs GT TT (3 studies) Outcome UC0.3381.092 (0.912-1.308)0.3381.092 (0.912-1.308)NS
C3435TT vs C (6 studies)0.0021.170 (1.062-1.289)0.0031.178 (1.058-1.311)NS
TT vs CC (5 studies)0.0081.332 (1.080-1.644)0.0171.367 (1.057-1.768)NS
G2677T/AG vs T (4 studies)0.8430.989 (0.887-1.103)0.8620.986 (0.836-1.162)NS
GG vs GT TT (3 studies) Outcome IBD0.9470.994 (0.830-1.190)0.9470.994 (0.830-1.190)NS
C3435TT vs C (6 studies)0.0831.074 (0.991-1.165)0.1351.083 (0.976-1.201)NS
TT vs CC (5 studies)0.2251.116 (0.935-1.332)0.2741.135 (0.904-1.426)NS
G2677T/AG vs T (5 studies)0.3511.041 (0.957-1.132)0.4481.047 (0.930-1.178)NS
GG vs GT TT (4 studies)0.3661.065 (0.929-1.221)0.3661.065 (0.929-1.221)NS