Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease

Table 1 Clinical parameters, histological staging, treatment profiles and disease outcome

Parameters	1st	2nd	3rd	4th	5th	6th	7th	8th	9th	10th	11th
Sex	M	M	M	M	M	M	F	M	M	F	M
Age (yr)	32	20	48	28	51	45	48	21	34	27	39
Clinical features
Diarrhea	+	+	+	+	-	+	+	+	+	+	+
Weight loss	+	+	+	+	-	+	+	+	+	+	+
Pain abd	+	+	-	+	+	+	-	+	+	-	+
Clubbing	+	-	+	+	+	-	+	+	-	-	+
Anemia	+	+	-	-	+	-	+	+	+	+	-
Fever	+	-	-	-	+	+	-	-	-	+	-
Endoscopy
Stomach	-	-	-	+ Infl	-	-	-	-	-	+ N	-
Duodenum	+	+	+(U)	+	+	+(U)	-	+	+(U)	+(U)	+
Jejunum	+	+	+	+	+	+	+	+	+	+(U)	+
Ileum	-	-	-	-	-	-	+	-	+	+	-
Colon	-	-	-	-	-	-	-	-	-	+	-
Radiology
Mesenteric LN	-	+	+	+	-	+	-	+	+	+	-
Hepatomegaly	-	-	-	-	-	-	-	-	+	+	-
Splenomegaly	-	-	-	-	-	-	-	-	-	+	-
Histology (S+D+J+C+R)
Number of tissue	4+4+0+0+0	4+4+0+0+0	5+3+0+0+0	2+4+4+0+0	3+4+0+0+0	4+5+0+0+0	4+5+0+0+0	3+5+0+0+0	3+4+3+0+0	2+3+3+3+4	4+4+0+0+0
Galian’s stage	A	A	A	A, HP	B	B	B	B	B	B	B
Light chain over-expression	λ	κ	κ	-ive	-ive	-ive	κ	-ive	κ	κ	κ
Drugs received	Dox	Dox Chm	Dox Chm	Anti-HP	Dox	Dox	Dox Chm	Dox	Dox Chm	Dox Chm	Dox
Disease relapse	-	+	+	-	-	-	+	-	+	+	-
Follow-up (mo)	120	36	29	40	165	93	No FU	46	No FU	No FU	57

Abbreviations: Infl = inflammation, N = nodular, U = ulceration, + = disease present, - = disease absent, HP = H pylori, Dox = doxycycline, Chm = Chemotherapy (CHOP regime), Anti-HP = anti-H pylori, S = stomach, D = duodenum, J = jejunum, C = colon, R = rectum.

Table 2 Immunoprofiles of the groups studied (mean ± SD)

Immuno-markers	Stage A	Stage B	Lymphoma	Normal
Syndecan-1	69 ± 3.40	51 ± 10.25	10.1 ± 6.354	11 ± 7.605
bcl6	1.75 ± 1.63	3.64 ± 3.541	4.25 ± 4.152	0.55 ± 0.51
p53	3.15 ± 3.257	6.5 ± 2.914	9.2 ± 4.315	0.11 ± 0.901
κ light chain	67.51 ± 16.952	67.42 ± 18.95	55 ± 2.399	42 ± 13.475
λ light chain	35 ± 13.857	24 ± 1.346	25.5 ± 1.087	29 ± 12.356
IgA heavy chain	72 ± 4.570	62 ± 24.521	22 ± 2.972	36 ± 6.513