Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptor α-chain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation

Table 1 Quantitative results of IL-11 expression in IEC-6 cells after 4.0Gy neutron irradiation (mean±SD)

Time after irradiation (h)	MOD (×10-2)	IOD (×10-1)
0	17.33 ± 1.16	17.30 ± 1.04
6	6.33 ± 0. 58 a	1.30 ± 0.17 a
24	24.67 ± 3.22	27.30 ± 2.59
48	14.33 ± 0. 58	13.33 ± 0.50

n = 3.

^aP < 0.05 vs normal control group.

Table 2 Quantitative results of IL-11 Rα expression in IEC-6 cells after 4.0Gy neutron irradiation (IHC) (mean±SD)

Time after irradiation (h)	MOD (×10-2)			IOD (×10-1)
	Normal	Neutron-radiated	rhIL-11 post-treatment	normal	Neutron- radiated	rhIL-11 post-treatment
6	8.60 ± 2.07	3.40 ± 0. 97b	10.50 ± 1.08a	24.25 ± 10.33	1.32 ± 1.04 b	42.76 ± 18.27 a
24	-	10.38 ± 1.23	17.80 ± 2.53 ba	-	37.95 ± 12.54	100.88 ± 47.57 a

n = 3.

^bP < 0.01 vs normal control group;

^aP < 0.05 vs neutron irradiation group.

Table 3 Quantitative results of IL-11Rα expression in IEC-6 cells after 4.0Gy neutron irradiation (mean±SD)

Time after irradiation (h)	MOD (×10-2)			IOD (×10-1)
	normal	Neutron-radiated	rhIL-11 post-treatment	normal	Neutron-radiated	rhIL-11 post-treatment
6	5.30 ± 0.10	3.07 ± 0. 31a	4.23 ± 0.12ac	82.13 ± 3.51	8.10 ± 2.45b	40.27 ± 2.64 bc
24	-	4.97 ± 0.15	5.33 ± 0.14c	-	44.80 ± 1.21 b	70.03 ± 2.2c

n = 3.

^aP < 0.05,

^bP < 0.01 vs normal control group;

^cP < 0.05, ^dP < 0.01 vs neutron irradiation group.

Table 4 Quantitative results of gp130 expression in IEC-6 cells after 4.0Gy neutron irradiation (mean±SD)

Time after irradiation (h)	MOD (×10-1)				IOD (×10-1)
	Normal	Neutron-radiated	rhIL-11 pretreatment	rhIL-11 post-treatment	Normal	Neutron- radiated	rhIL-11 pretreatment	rhIL-11 post-reatment
6	4.90 ± 0.44	3.70 ± 0.17	3.83 ± 0.06	5.37 ± 0.58a	51.07 ± 16.75	26.27 ± 10.25b	35.60 ± 4.03	68.60 ± 5.19c
24	-	2.70 ± 0.15a	5.53 ± 0.08c	5.50 ± 0.11c	-	19.13 ± 5.14b	89.79 ± 5.12ad	75.87 ± 0.68c
48	-	1.61 ± 0.10a	4.47 ± 0.15d	2.63 ± 0.15c	-	7.46 ± 0.50b	41.33 ± 13.55ac	18.70 ± 0.10bc

n = 3.

^aP < 0.05,

^bP < 0.01 vs normal control group;

^cP < 0.05,

^dP < 0.01 vs neutron irradiation group.