Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

Table 1 Baseline characteristics of 991 patients with coronary artery disease started on low-dose aspirin (mean ± SD, n, %)

	No UGIB	UGIB	P values
	(n = 962)	(n = 29)
Age (mean ± SD)	64 ± 11	67 ± 11	0.663
Sex (M/F)	693/268	23/6	0.683
Hypertension (%)	519 (54)	22 (76)	0.008
Diabetes mellitus (%)	342 (35.5)	10 (34.5)	0.906
Renal impairment (Cr > 200 umol/L) (%)	42 (4.4)	5 (17.2)	0.001
Serum creatinine	120 ± 93	158 ± 103	0.002
History of MI (%)	536 (56)	16 (55)	0.095
History of PU (%)	74 (7.7)	9 (31.0)	0.006
LVEF < 40% (%)	388 (40.3)	11 (37.9)	0.034
NYHA (III-IV) (%)	82 (8.5)	6 (20.7)	0.048
% Body fat	34 ± 7	30 ± 7	0.036
% Lean body mass	66 ± 8	70 ± 7	0.049
Education level (tertiary) (%)	107 (11.1)	5 (17.2)	0.05
Nitrate use (%)	540 (56.1)	21 (72.4)	0.09

Cr: creatinine; MI: myocardial infarction; PU: peptic ulcer; LVEF: left ventricular ejection fraction; NYHA: New York Heart Association functional class.

Table 2 Multivariate analysis of predictors of upper gastrointestinal bleeding in patients with coronary artery disease on low-dose aspirin (mean ± SD)

	95%CI	Odds ratio	P values
Education level (tertiary)	1.05 - 8.98	3.08	0.039
Hypertension	1.46 - 14.74	4.63	0.009
History of peptic ulcer	1.05 - 9.00	3.08	0.039
% Lean body mass (body fat content)			0.0157