Effect of WeiJia on carbon tetrachloride induced chronic liver injury

doi:10.3748/wjg.v12.i12.1912

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Mar 28, 2006 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Mar 28, 2006; 12(12): 1912-1917
Published online Mar 28, 2006. doi: 10.3748/wjg.v12.i12.1912

Table 1 Liver fibrosis serum markers test for rats in different treatment group

Group	5^th wk	8^th wk
	HA µg/L	CIV µg/L	HA µg/L	CIV µg/L
A	43 ± 19	19 ± 10	37 ± 17	46 ± 16
B^b	324 ± 92	206 ± 70	130 ± 52	136 ± 28
C^a	66 ± 20^c	74 ± 19^c	58 ± 22^c	57 ± 21¹

n = 7 for each group,

^aP<0.005 vs Group B,

^b < 0.001 vs Group A,

^cP < 0.05 vs Group A,

¹P > 0.1 vs Group A.

Table 2 Degree of fibrosis for rats in different treatment group

Group	5^th wk	8^th wk
	F0	F1	F2	F3	F4	F0	F1	F2	F3	F4
A	7					7
B^b		3	4					1	6
C^a^d		5	2				3	3	1

n = 7 for each group,

^aP > 0.05 vs Group B at fifth week,

^bP < 0.01 vs Group A,

^dP < 0.01 vs Group B at eighth week.

Table 3 Ballooning degeneration and steatosis for rats in different treatment group

Group		5^th wk 8^th wk
	0	1	2	3	0	1	2	3
A	7				7
B^b			3	4		1	2	4
C^a		1	6			4	3

n = 7 for each group,

^aP < 0.05 vs Group B,

^bP < 0.01 vs Group A.

Table 4 Percentage collagen content for rats in different treatment groups

Group	5^th wk	8^th wk
A	0	0
B ^b	5.2 ± 1.6	7.3 ± 1.6
C	3.8 ± 0.9^a	4.7 ± 1.0^c

n = 7 for each group,

^aP > 0.05 vs Group B,

^bP < 0.01 vs Group A,

^cP < 0.05 vs Group B.

Table 5 Liver function tests for rats in different treatment group

Group		5^th wk 8^th wk
	ALT U/L	AST U/L	γ-GT U/L	ALT U/L	AST U/L	γ-GT U/L
A	34 ± 12	99 ± 12	13 ± 7	32 ± 9	100 ± 19	15 ± 12
B^a	135 ± 24	158 ± 19	45 ± 23	133 ± 34	166 ± 28	74 ± 36
C	43 ± 12^b^e	118 ± 10^b^f	28 ± 19^d^e	47 ± 10^b^g	139 ± 13^c^f	52 ± 21^d^f

n = 7 for each group,

^aP < 0.005 vs Group A,

^bP < 0.001 vs Group B,

^cP < 0.05 vs Group B,

^dP > 0.1 vs Group B,

^eP > 0.05 vs Group A,

^fP < 0.01 vs Group A,

^gP < 0.05 vs Group A.

Table 6 Expression of PCNA and α-SMA of rats in different treatment group

Group	5^th wk	8^th wk
	PCNA	α-SMA	PCNA	α-SMA
A	17.4 ± 7.0	1.4 ± 0.5	16.6 ± 7.8	1.3 ± 0.5
B	27.9 ± 8.3^a	4.9 ± 2.3^b	21.0 ± 5.4^c	4.6 ± 1.5^b
C^g	43.4 ± 14.0^e	3.7 ± 2.1¹	31.0 ± 10.0^e	2.6 ± 1.0^e

n = 7 for each group,

^aP < 0.05 vs Group A,

^bP < 0.01 vs Group A,

^cP > 0.05 vs Group A,

¹P > 0.1 vs Group B,

^eP < 0.05 vs Group B,

^gP < 0.05 vs Group A.

Citation: Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MCM, Chan B, Fong CC, Shi L, Shi YF, Chun J, Kung HF, Yang M. Effect of WeiJia on carbon tetrachloride induced chronic liver injury. World J Gastroenterol 2006; 12(12): 1912-1917
URL: https://www.wjgnet.com/1007-9327/full/v12/i12/1912.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i12.1912