Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes

Table 1 Subject characteristics and plasma glucose, insulin, and lipid levels

Parameter	Control group	Non-obese diabetes group	Obese diabetes group
n	28	30	30
Age (yr)	47 ± 11	48  ±  8	52  ±  9
Gender (M/F)	14/14	14/16	16/14
BMI (kg/m2)	24.03 ± 4.05	23.13 ± 1.62	27.25 ± 1.71ac
FPG (mmol/L)	4.97 ± 0.56	9.9 ± 2.03a	10.03 ± 2.08a
FINS (mU/L)	6.25 ± 4.22	9.52 ± 7.81	8.72 ± 4.64
IR	0.50 ± 0.35	0.98 ± 0.59a	1.22 ± 0.53a
ISI	-3.61 ± 0.35	-4.09 ± 0.59a	-4.33 ± 0.54a
TCH (mmol/L)	4.79 ± 1.07	5.79 ± 1.42a	5.61 ± 1.79a
TG (mmol/L)	1.48 ± 1.74	2.45 ± 1.46a	3.05 ± 1.92a
NEFA (mmol/L)	0.71 ± 0.18	0.95 ± 0.21a	1.13 ± 0.24a

BMI: body mass index; FPG: fasting plasma glucose; FINS: fasting insulin; IR: insulin resistance; ISI: insulin sensitive index; TCH: total cholesterol; TG: plasma triglyceride; NEFA: non-esterified fatty acids. ^aP < 0.05 vs control group; ^cP < 0.05 vs non-obese diabetes group.

Table 2 Plasma adiponectin and resistin levels in diabetes patients divided by body weight

	Control group	Non-obese diabetes group	Obese diabetes group
Adiponectin (mg/L)	10.53±1.47	8.58±0.86a	6.22±1.34ac
Resistin (mg/L)	14.16±5.25	18.64±4.65a	24.05±9.07ac

^aP < 0.05 vs control group; ^cP < 0.05 vs non-obese diabetes group.

Table 3 Correlation analysis of fasting plasma adiponectin and resistin with the other parameters

	Adiponectin		Resistin
Parameter	r	P value	r	P value
BMI	-0.55	0	0.4	0
FPG	-0.51	0	0.52	0
FINS	0.15	0.16	0.1	0.39
IR	-0.52	0	0.46	0
ISI	0.45	0	-0.32	0
TCH	-0.15	0	0.07	0.53
TG	-0.39	0.02	0.27	0.01
NEFA	-0.45	0	0.29	0

BMI: body mass index; FPG: fasting plasma glucose; FINS: fasting insulin; IR: insulin resistance; ISI: insulin sensitive index; TCH: total cholesterol; TG: plasma triglyceride; NEFA: non-esterified fatty acids. ^aP < 0.05 vs control group; ^cP < 0.05 vs non-obese diabetes group.