Editorial
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2006; 12(11): 1657-1670
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1657
Table 1 Affinity constants of sugar transporters
TransporterKm
SGLT1 (BBM)Glucose:0.1-0.6 mmol/L
(Wright et al, 2003)
GLUT2 (BLM)Glucose:> 50 mmol/L
Fructose: 66 mmol/L
(Walmsley et al, 1998)
GLUT5 (BBM)Fructose: 6-14 mmol/L
(Walmsley et al, 1998)
Table 2 Inhibitors of sugar transporters
Inhibitors
SGLT1Phloridzin
GLUT2Cytochalasin B
Phloretin
GLUT5Glyco-1, 3-oxazolidin-2- thiones, -ones (Girniene et al, 2003)
Na+K+-ATPaseOubain
Table 3 Factors influencing transporter function
Factors influencingFactors influencingFactors influencing
SGLT1 functionGLUT2 functionGLUT5 function
Foxl1 (Katz et al, 2004)PKCbII(Helliwell et al, 200b)cAMP (Mahraoui et al, 1994)
AMPK (Walker et al, 2004)p38(Helliwell et al, 200b)p38 (Helliwell et al, 200b)
PKA (Wright et al, 1997)ERK(Helliwell et al, 200b)ERK (Helliwell et al, 200b)
PKC (Wright et al, 1997)PI3K(Helliwell et al, 200b)PI3K (Helliwell et al, 200b)
RS1 (Veyhl et al, 1993)mTOR (Helliwell et al, 2003)TNF-α (Garcia-Herrera, 2004)
HNF-1 (Martin et al, 2000)AMPK (Walker et al, 2004)
Sp1 (Martin et al, 2000)
Hsp 70 (Ikari et al, 2002)
TGF-b (Ikari et al, 2002)