Protective effect of Radix Acanthopanacis Senticosi capsule on colon of rat depression model

Table 1 Open-field activities and sucrose intake test of rats (mean±SD).

Group	Cases n	Rearing/5 min	Crossing/5 min	Sucrose intake mL/24 h
Normal	10	32.20±11.14	82.50±29.62	42.70±10.24
Model	50	13.96±5.57b	37.80±12.32b	28.02±8.91b

^bP<0.01 vs normal group.

Table 2 Effects of RAS capsule on SOD activity, MDA content and COX-2 expression in the colon tissue of depression model rats (n =10, mean±SD).

Group	Dose (mg/kg)	SOD (U/mg prot)	MDA (nmoL/mg prot)	COX-2 (A/%)
Normal	-	84.45±22.31	2.55±0.70	4.87±1.65
Model	-	53.39±11.15d	10.34±2.77d	53.2±68.16a
5-ASA	100	72.73±12.60bc	3.19±1.15b	24.59±9.14bd
RAS	300	70.81±12.36bc	2.92±0.75b	50.40±10.66d
RAS	600	73.30±15.30bc	3.19±1.08b	28.83±9.48bd
RAS	900	69.09±11.03bc	3.26±1.24b	27.04±9.56bd

^aP<0.05,

^bP<0.01 vs model group;

^cP<0.05,

^dP<0.01 vs normal group.

Table 3 Effects of RAS capsule on the content of iNOS and NO in colon tissue of depression model rats (n =10, mean±SD).

Group	Dose (mg/kg)	iNOS (U/mg prot)	NO (mmoL/g prot)
Normal	-	0.25±0.16	4.761.55
Model	-	1.11±0.44d	11.28±5.66d
5-ASA	100	0.63±0.42bc	5.89±2.10d
RAS	300	0.65±0.31ac	5.99±2.73b
RAS	600	0.58±0.22bc	6.87±1.96a
RAS	900	0.64±0.33bc	6.5±01.58a

^aP<0.05,

^bP<0.01 vs model group;

^cP<0.05,

^dP<0.01 vs normal group.