Morphological and serum hyaluronic acid, laminin and type IV collagen changes in dimethylnitrosamine-induced hepatic fibrosis of rats

Table 1 Changes in the weight of body and liver as well as liver/body ratio of rats during DMN treatment (mean±SD)

Group	n	Body weight	Liver weight	Liver/body ratio
Control	10 (0)	192.50±9.0446	6.2260±0.3848	3.2191±0.2829
Day 7	6 (4)	207.85±5.3293	7.8114±0.3869	3.7492±0.1195
Day 14	9 (1)	167.27±11.9157a	6.9164±0.6229a	4.1059±0.1636a,c
Day 21	9 (1)	181.11±13.3536a	6.5122±0.6200a	3.5671±0.1437a
Day 28	10 (0)	186.42±10.7301a	6.3657±0.5306a	3.3903±0.1096a,c

^aP<0.05 vs control; ^cP<0.05 vs day 7; ( ): number of deaths.

Table 2 Pathologic grading of DMN-induced hepatic fibrosis in rats (mean±SD)

Groups	n	Grading of hepatic fibrosis
		–	+	++	+++	++++
Control	10 (0)	10	0	0	0	0
Day 7	6 (4)	0	3	3	0	0
Day 14	9 (1)	0	2	4	3	3
Day 21	9 (1)	0	0	2	4	3
Day 28	10 (0)	0	0	2	4	4

P<0.001 vs control; P<0.001 vs d 7; ( ): number of deaths.