Viral Hepatitis
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2005; 11(48): 7560-7563
Published online Dec 28, 2005. doi: 10.3748/wjg.v11.i48.7560
Table 1 Presenting features of the studied patients
Treated group (n = 14)
Untreated group (n = 9)
BaselinePost losartanBaselineSecond biopsy
Females/males4/141/8
Age (yr)49.6±13
Hematocrit45.2±3.5944.1±3.8548.8±4.6647.8±4.15
White blood cells (K/mm3)6.66±1.416.71±1.675.98±0.955.78±1.19
Platelets (K/mm3227±80.8246±90.7b223±68209±78.4
Glucose (g/L)0.99±0.381±0.290.95±0.11.01±0.06
Blood urea nitrogen (g/L)0.31±0.060.32±0.060.28±0.070.25±0.04
Creatinine (mg/dL)0.88±0.070.95±0.110.99±0.070.96±0.12
Total bilirubin (mg/dL)1±0.531.08±0.631.35±0.581.19±0.58
Alkaline phosphatase (IU/L)253±118269±68.9264±93.4349±134
Alanine aminotransferase (IU/L)90.5±6691.9±47.6264±167a169±124
Aspartate aminotransferase (IU/L)65.3±4167±40.9161±97.8a130±84.5
Cholesterol (mg/dL)157±36.4161±42.6166±38.1169±39.2
Albumin (g/dL)4.12±0.324.43±0.24b4.32±0.564.32±0.5
Globulins (g/dL)3.64±0.533.77±0.453.74±0.633.91±0.63
G glutamyl transpeptidase (IU/ L)63.2±47.974.5±53.7194±178a217±214
Prothrombin time (%)103±19.3106±17.4107±8.1997±9.83
KPTT (s)32.6±3.3839.6±18.737.8±6.9934.5±2.38
Table 2 Histological changes in liver biopsies
Treated group (n = 14)
Untreated group (n = 9)
BaselinePost losartanBaselineSecond biopsy
Histology activity index8.08±2.568.54±1.517.0±2.127.6±2.3
Fibrosis stage3.29±1.442.64±1.222.67±23.56±2.13
Sub-endothelial fibrosis (pixels/inch2)2.48±1.041.00±0.53a1.65±0.431.55±0.27
Table 3 Changes in arterial pressure after losartan administration
Baseline3 h1 mo
Systolic arterial pressure (mmHg)134±22.7125±17.4a124±18.1a
Diastolic arterial pressure (mmHg)80.8±1481.2±14.282.5±13.7
Mean arterial pressure (mmHg)98.4±16.395.7±14.8100±15.8
Table 4 Orthostatic variations in arterial pressure after losartan administration
SupinepositionSittingposition
Baseline (10:00 am)
Systolic arterial pressure (mmHg)132.7±22.1132.2±16.8
Diastolic arterial pressure (mmHg)80.7±13.487.8±8.93(P<0.0001)
Mean arterial pressure (mmHg)98±15.7102.6±11.1(P<0.01)
Three hours post losartan
Systolic arterial pressure (mmHg)124. 7±17.4127.3±14.9
Diastolic arterial pressure (mmHg)81.1±14.283.5±11.1
Mean arterial pressure (mmHg)95. 7±14.898.1±12