Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy

Table 1 Level of obligate and facultative anaerobes in Group1 and Group2, before H pylori eradication therapy (mean±SD)

Population	LogCFU/g
	Group 1 (n = 17)		Group 2 (n = 18)
Total counts	10.4±0.4		10.2±0.5
Obligate anaerobes	10.4±0.4		102±0.6
Bacteroidaceae	10.1±0.4	(100)	9.3±1.6	(100)
Bifidobacteria	9.8±0.6	(93.8)	9.6±0.6	(93.8)
Peptococci	8.9±0.8	(62.5)	9.0±0.5	(62.5)
Clostridia	7.5±1.9	(93.8)	7.9±1.5	(100)
Micrococci	3.0±1.2	(25)	3.5±1.8	(37.5)
Facultative anaerobes	8.3±0.7		8.1±1.0
Enterobacteriaceae	7.2±1.7	(93.8)	6.7±1.5	(100)
E.coli	7.3±1.4	(81.3)	6.4±1.6	(93.8)
Others	6.9±1.8	(18.8)	5.7±1.0	(31.3)
Enterococci	7.3±1.1	(93.8)	7.9±1.0	(93.8)
Lactobacilli	7.2±1.6	(100)	6.9±1.0	(93.8)
Bacilli	7.6±0.9	(37.5)	7.4±0.6	(25)
Yeasts	5.0±2.0	(75)	4.8±1.8	(56.3)

There are no significant differences between the two groups using Mann-Whitney U test. Figures in parentheses are detection rates.

Table 2 Detection rates of fecal flora

		Detection rates (%)
Population	Group	Before	D2	D4	D8	D15	D22
Bacteroidaceae	1	100	100	93.8	100	100	93.3
	2	100	94.4	100	100	100	94.4
Bifidobacteria	1	93.8	62.5a	50.0b	62.5a	68.8	73.3
	2	93.8	66.7	44.4b	72.2	66.7	66.7
Clostridia	1	93.8	93.8	75	100	100	100
	2	100	94.4	94.4	94.4	100	100
Enterobacteriaceae	1	93.8	93.8	100	93.8	100	100
	2	100	94.4	100	94.4	100	100
E.coli	1	81.3	62.5	25	37.5a	87.5	93.3
	2	93.8	72.2	94.4	66.7b	88.9	77.8
Others	1	18.8	75.0b	81.3d	75	81.3d	46.7
	2	31.3	27.8	16.7	38.9	33.3	50
Enterococci	1	93.8	87.5	81.3	100	100	100
	2	93.8	100	100	100	100	100
Lactobacilli	1	100	87.5	68.8a	43.8d	93.8	93.3
	2	93.8	61.1a	61.1a	44.4b	100	88.9
Yeasts	1	75	93.8	100.0a	93.8	87.5	86.7
	2	56.3	61.1	72.2	83.3	44.4	66.7

^aP<0.05,

^bP<0.01,

^dP<0.001 vs before, Fisher’s exact test.

Table 3 Clinical symptoms observed during and after H pylori eradication therapy

	Group 1 (n = 17, %)		Group 2 (n = 18, %)
Loose stool	8	(47.1)	4	(22.2)
Water diarrhea	2	(11.8)	1	(5.6)
Abdominal pain	2	(11.8)	0	(0)
Abdominal distention	2	(11.8)	0	(0)