Histological outcome of chronic hepatitis B in children treated with interferon alpha

Table 1 Morphological evaluation of liver biopsies in children with chronic hepatitis B treated with IFN-α (n = 93)

Scoring system	Baseline biopsy	Final biopsy
Batts grade	1.516±0.619	1.312±0.51a
Batts stage	1.892±0.598	1.839±0.631
Ishak grade	4.054±1.683	3.344±1.514b
Ishak stage	2.462±1.006	2.398±1.034
METAVIR stage	1.667±0.712	1.645±0.702

^aP<0.05 vs baseline biopsy;

^bP<0.01 vs baseline biopsy.

Table 2 Morphological evaluation of liver biopsies in children with chronic hepatitis B treated with IFN-α in the subgroups of responders (n = 35) and nonresponders (n = 58)

Scoring system	Subgroups	Baseline biopsy	Final biopsy
Batts grade	Nonresponders	1.431±0.596	1.379±0.524
	Responders	1.657±0.639	1.2±0.473b
Batts stage	Nonresponders	1.793±0.554	1.81±0.606
	Responders	2.057±0.639	1.886±0.676
Ishak grade	Nonresponders	3.81±1.503	3.43±1.403
	Responders	4.457±1.899	3.2±1.694b
Ishak stage	Nonresponders	2.293±0.878	2.431±0.901
	Responders	2.743±1.146	2.343±1.255
METAVIR stage	Nonresponders	1.62±0.644	1.638±0.667
	Responders	1.743±0.816	1.657±0.764

^bP<0.01 vs baseline biopsy.

Table 3 Correlations between staging and grading according different histological scoring systems

Scoring system	Batts grade	Batts stage	Ishak grade	Ishak stage	METAVIR stage
Batts grade	-	r = 0.385	r = 0.825	r = 0.392	r = 0.405
		P = 0.00014	P = 0.0000001	P = 0.0001	P = 0.00005
Batts stage	r = 0.385	-	r = 0.522	r = 0.713	r = 0.713
	P = 0.00014		P = 0.0000001	P = 0.0000001	P = 0.0000001
Ishak grade	r = 0.825	r = 0.522	-	r = 0.409	r = 0.41
	P =0.0000001	P = 0.0000001		P = 0.000045	P = 0.000045
Ishak stage	r = 0.392	r = 0.713	r = 0.409	-	r = 0.758
	P = 0.0001	P = 0.0000001	P = 0.000045		P = 0.0000001
METAVIR stage	r = 0.405	r = 0.713	r = 0.41	r = 0.758	-
	P = 0.00005	P = 0.0000001	P = 0.000045	P = 0.0000001