Copyright
©The Author(s) 2005.
World J Gastroenterol. Oct 21, 2005; 11(39): 6134-6143
Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6134
Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6134
Genes | Forward | Reverse |
IL-8 | 5’-GCT TTC TGA TGG AAG AGA GC-3’ | 5’-GGC ACA GTG GAA CAA GGA CT-3’ |
c-fos | 5’-GTC AAG AGC ATC AGC AGCA T-3’ | 5’-TCG GGG TAG GTG AAG ACG AA-3’ |
HNRPDL | 5’-GTT TCA GAG GAC CTG GAA TA-3’ | 5’-TCA CTA CCC TAG ACA CCG CA3’ |
Vinculin | 5’-CAA GTG TGA CCG AGT GGA CC-3’ | 5’-TTG GTA TCA ATG GCT TCG TC-3’ |
DSS1 | 5’-CAA GTC TCT ATG GTA GCG TCA GC-3’ | 5’-ACC ATG TTT CTC TAG TTC AG-3’ |
NDRG1 | 5’-GGC GCG ACC TGG AGA TGAG-3’ | 5’-CTA GCA GGA GAC CTC CAT GG-3’ |
EMK-1 | 5’-GAG ATG GAG GTG TGC AAA CT-3’ | 5’-TGG TTT AGG CGA AAT ACT CT-3’ |
GAPDH | 5’-ACC ACA GTC CAT GCC ATC AC-3’ | 5’-TCC ACC ACC CTG TTG CTG TA-3’ |
Cluster | Function | No. of the genes (Total) | P-value |
C-1 | Chaperon activity | 12 (31) | 0.019 |
Transcription regulator activity | 29 (92) | 0.033 | |
C-2 | Apoptosis regulator activity | 7 (9) | <0.01 |
Cell adhesion molecule activity | 18 (39) | <0.01 | |
Signal transducer activity | 47 (132) | 0.034 | |
Transcription regulator activity | 9 (20) | 0.037 | |
Structural molecular activity | 40 (113) | 0.049 | |
C-3 | Antioxidant activity | 6 (8) | <0.01 |
C-4 | Lyase activity | 8 (10) | 0.011 |
Chaperon activity | 10 (31) | 0.037 |
Acc. Number | Gene Symbol | Name | Function | 1.5h | 3h | 6h | 12h |
U79243 | LZTR1 | leucine-zipper-like transcriptional regulator 1 | transcription | 5.08 | 3.08 | 0.95 | 2.30 |
X61118 | LMO2 | LIM domain only 2 (rhombotin-like 1) | tumor associated | 2.53 | 16.24 | 0.28 | 1.04 |
BC004247 | RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1) | adhesion/cytoskeleton | 1.13 | 4.78 | 0.89 | 1.29 |
AF005043 | PARG | poly (ADP-ribose) glycohydrolase | metabolism | 0.58 | 0.62 | 14.72 | 0.53 |
U86782 | POH1 | 26S proteasome-associated pad1 homolog | RNA/Protein processing | 2.55 | 3.59 | 7.24 | 3.56 |
M62839 | APOH | apolipoprotein H (beta-2-glycoprotein I) | immunity | 0.49 | 3.49 | 0.65 | 1.47 |
BC004980 | SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter) member 1 | metabolism | 4.07 | 0.81 | 0.95 | 1.54 |
Z26649 | PLCB3 | phospholipase C beta 3 (phosphatidylinositol-specific) | tumor associated | 2.49 | 3.32 | 0.75 | 2.52 |
M62399 | RELA | v-rel reticuloendotheliosis viral oncogene homolog A nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 p65 (avian) | apoptpsis | 2.84 | 3.24 | 1.43 | 1.13 |
BC000665 | TCP1 | t-complex 1 | RNA/Protein processing | 1.73 | 3.21 | 1.05 | 1.41 |
V01512 | c-fos | V01512|HSCFOS Human cellular oncogene c-fos (complete sequence). | tumor associated | 37.81 | 2.48 | 0.57 | 0.91 |
BC000117 | GMDS | GDP-mannose 46-dehydratase | metabolism | 2.63 | 4.37 | 2.28 | 3.75 |
L29218 | CLK2 | CDC-like kinase 2 | growth/maintenance | 1.46 | 4.03 | 1.96 | 0.60 |
BC000771 | NTRK1 | neurotrophic tyrosine kinase receptor type 1 | tumor associated | 3.33 | 3.47 | 1.42 | 3.59 |
X68836 | MAT2A | methionine adenosyltransferase II alpha | metabolism | 3.14 | 2.95 | 0.85 | 1.28 |
X94232 | MAPRE2 | microtubule-associated protein RP/EB family member 2 | growth/maintenance | 0.58 | 3.23 | 0.69 | 0.29 |
X80200 | TRAF4 | TNF receptor-associated factor 4 | signal transduction | 3.20 | 3.02 | 3.67 | 1.08 |
D76444 | ZFP103 | zinc finger protein 103 homolog (mouse) | growth/maintenance | 1.38 | 2.63 | 3.99 | 1.78 |
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Citation: Shibata W, Hirata Y, Yoshida H, Otsuka M, Hoshida Y, Ogura K, Maeda S, Ohmae T, Yanai A, Mitsuno Y, Seki N, Kawabe T, Omata M. NF-kB and ERK-signaling pathways contribute to the gene expression induced by
cag PAI-positive-Helicobacter pylori infection. World J Gastroenterol 2005; 11(39): 6134-6143 - URL: https://www.wjgnet.com/1007-9327/full/v11/i39/6134.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i39.6134