Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis

Table 1 Demographic, clinical, biochemical and histological findings and H pylori status in 140 patients with atrophic body gastritis (ABG)

	Perniciousanemia	Irondeficiencyanemia	Dyspepsia
Demographic and clinical features
Patients (%)	65 (46.5)	57 (40.7)	18 (12.8)
Gender (M/F)	34/31a	8/49e	7/11
Age, yr	63 (30-83)a	46 (22-78)	56 (31-81)
Associated autoimmune	11 (16.9)	10 (17.5)	4 (22.2)
disease, n (%)
Biochemical features and gastric autoantibodies
Gastrin, pg/mL	500 (55-2 700)b	375 (50-1 650)	370 (49-950)
Pepsinogen I, ng/mL	5 (0-68) b	10 (0-72)	10 (2-84)
PAO1, mEq/h	0 (0-11.6)	0 (0-11.9)	0 (0-12.5)
PCA positive2, n (%)	46 (70.7)	38 (66.6)	15 (83)
IFA positive3, n (%)	32 (49.2)a	12 (21.1)	5 (27.8)
Vitamin B12, pg/mL	80 (13-394)ad	200 (80-701)	195 (100-760)
Histological features
Body atrophy, n (%)	65 (100)	57 (100)	18 (100)
Body atrophy score	2.83 ± 0.06ad	2.1 ± 0.10	1.94 ± 1.7
Antral atrophy, n (%)	15 (23.1)	14 (24.6)	7 (38.9)
Antral atrophy score	1.47 ± 0.13	1.29 ± 0.13	1.29 ± 0.18
Antrum spared, n (%)	30 (46.1)	25 (43.8)	4 (22.2)
H pylori positive4, n (%)	40 (61.5)ac	51 (89.5)	16 (88.9)

^aP < 0.05 iron deficiency anemia,

^bP < 0.001 vs iron deficiency anemia,

^cP < 0.05 vs dyspepsia,

^dP < 0.001 vs dyspepsia,

^eP < 0.05 iron deficiency anemia vs dyspepsia. Data are expressed as median (range) and mean±SE.

¹Peak acid output,

²parietal cell antibodies,

³intrinsic factor antibodies,

⁴sum of H pylori positive patients at histology and at serology.

Table 2 Demographic, clinical, biochemical and histological findings in 140 patients with atrophic body gastritis (ABG)

.	IFA positive	IFA negative	P
Demographic and clinical features
Patients (%)	49 (35)	91 (65)
Gender (M/F)	18/31	31/60	NS
Age, yr, median (range)	58 (26-83)	55 (22-78)	NS
Pernicious anemia, n (%)	32 (65.3)	33 (36.3)	P = 0.0013
Iron deficiency anemia, n (%) 12 (24.5)		45 (49.4)	P = 0.0042
Dyspepsia, n (%)	5 (10.2)	13 (14.3)	NS
Associated autoimmune	10 (20.4)	15 (16.5)	NS
disease, n (%)
Biochemical features and gastric autoantibodies
PCA positive1, n pts (%)	39 (80)	70 (77)	NS
Gastrin (pg/ mL)	500 (55-2.500)	405 (49-2.700)	P = 0.0579
median (range)
Pepsinogen I (ng/mlL)	5 (0-72)	10 (0-84)	P = 0.0027
median (range)
Histological features
Body atrophy score	2.67 ± 0.09	2.28 ± 0.08	P = 0.0028
(mean ± SE)
Antral atrophy, n (%)	10 (20.4)	26 (28.6)	NS
Antral atrophy score	1.2 ± 0.13	1.42 ± 0.1	NS
(mean ± SE)
Antrum spared, n (%)	22 (44.9)	37 (40.7)	NS
H pylori positive2, n (%)	37 (76)	70 (77)	NS

¹Parietal cell antibodies,

²sum of H pylori positive patients at histology and at serology. NS = not significant.