Damme NV, Demetter P, Bock WD, Rottiers M, Praet M, Hemptinne B, Peeters M. Limited influences of chemotherapy on healthy and metastatic liver parenchyma. World J Gastroenterol 2005; 11(34): 5322-5326 [PMID: 16149139 DOI: 10.3748/wjg.v11.i34.5322]
Corresponding Author of This Article
Nancy Van Damme, PhD, Department of Gastroenterology, Ghent University Hospital, De Pintelaan 185, 1K12IE, Ghent 9000, Belgium. nancy.vandamme@ugent.be
Article-Type of This Article
Clinical Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 14, 2005; 11(34): 5322-5326 Published online Sep 14, 2005. doi: 10.3748/wjg.v11.i34.5322
Table 1 Colorectal cancer patients’ characteristics
Number
Sex (M/F)
27/12
Location
Sigmoid
12
Rectum
6
Rectosigmoid
4
Cecum
4
Colon ascendens
3
Colon descendens
1
Splenic feature
2
Bauhin’s valve
1
Not specified
6
Table 2 Twenty-three patients received chemotherapy before the liver resection
Type of chemotherapy
Number
5-FU, LV, oxaliplatin
7
5-FU, LV, CPT-11
2
5-FU, LV
5
Cetuximab, FOLFIRI
1
Cetuximab, CPT-11
1
CPT-11
1
Oxaliplatin, capecitabine, CPT-11
1
Others
5
Table 3 Positive staining of the adhesion molecules in normal and metastatic liver parenchyma
Normal (%)
Metastatic (%)
E-cadherin
39/39 (100)
37/38 (97.37)
β-catenin
35/39 (89.74)
36/38 (94.74)
γ-catenin
18/39 (46.15)
25/38 (65.79)
VEGF
39/39 (100)
32/38 (84.21)
p53
0/39 (0)
25/38 (65.79)
Table 4 Expression of the adhesion molecules in normal and metastatic liver parenchyma (median and range)
Normal
Metastatic
Chemotherapy (n = 23)
No chemotherapy (n = 16)
Chemotherapy (n = 23)
No chemotherapy (n = 16)
E-cadherin
3 (2-4)
3 (2-6)
3 (0-6)
4 (2-6)
β-catenin
3 (0-5)
3 (0-5)
6 (0-6)
5 (0-6)
γ-catenin
0 (0-3)
1 (0-2)
2 (0-4)
2 (0-4)
VEGF
5 (3-5)
5 (3-5)
4 (0-5)
3 (0-4)
p53
0 (0-0)
0 (0-0)
3 (0-6)
2.5 (0-6)
Table 5 Percentage of macro- and microvesicular steatosis (median and range)
Chemotherapy (n = 23, %)
No chemotherapy (n = 16, %)
Macrovesicular
10 (0-40)
10 (0-30)
Microvesicular
0 (0-10)
0 (0-10)
Citation: Damme NV, Demetter P, Bock WD, Rottiers M, Praet M, Hemptinne B, Peeters M. Limited influences of chemotherapy on healthy and metastatic liver parenchyma. World J Gastroenterol 2005; 11(34): 5322-5326