Effect of lactulose on establishment of a rat non-alcoholic steatohepatitis model

Table 1 Rat body weight and the liver exponent (mean±SD)

Group	Time (wk)	n	Body weight (g)	Liver exponent (%)
Control	16	6	478.2±36.8	2.27±0.28
Model	8	12	425.8±26.7	3.37±0.05b
	16	12	505.8±60.1	3.93±0.51b
Treatment	16	12	433.3±58.2a	2.96±0.24a

^aP<0.05 vs model group;

^bP<0.01 vs control group.

Table 2 Serum lipid changes (mean±SD)

Group	Time (wk)	n	TG (mmol/L)	TC (mmol/L)
Control	16	6	0.83±0.20	1.10±0.18
Model	8	12	0.68±0.18	1.81±0.30b
	16	12	0.83±0.22	2.00±0.38b
Treatment	16	12	0.44±0.14a	2.06±0.32

^aP<0.05 vs model group;

^bP<0.01 vs control group.

Table 3 Serum aminotransferase changes (mean±SD)

Group	Time (wk)	n	ALT (U/L)	AST (U/L)
Control	16	6	34.16±5.17	144.00±21.59
Model	8	12	64.54±40.54	224.45±54.07
	16	12	94.92±45.50a	282.7±77.48b
Treatment	16	12	47.8±11.0c	133.7±26.5d

^aP<0.05,

^bP<0.01 vs control group,

^cP<0.05,

^dP<0.01 vs model group.

Table 4 Rat blood endotoxin level (mean±SD)

Group	Time (wk)	n	Serum endotoxin level (EU/mL)
			Portal vein	Abdominal aorta
Control	16	6	0.291±0.08	0.125±0.03
Model	8	12	0.264±0.07	0.089±0.02
	16	12	0.285±0.08	0.114±0.02
Treatment	16	12	-	-

Table 5 Degree of hepatic steatosis in different groups

Group	Time (wk)	n	Degree of steatosis
			-	+	++	+++
Control	16	6	6	0	0	0
Model	8	12	0	1	6	5
	16	12	0	0	1	11
Treatment	16	12	0	0	4	8

Table 6 Score of rat hepatic inflammation activity (mean±SD)

Group	Time (wk)	n	Score of inflammation activity
Control	16	6	0.66±0.76
Model	8	12	1.98±0.90
	16	12	5.83±2.02b
Treatment	16	12	3.63±0.64a

^aP<0.05 vs model group;

^bP<0.01 vs control group.