Effects of sulfasalazine on biopsy mucosal pathologies and histological grading of patients with active ulcerative colitis

Table 1 Effect of SASP on small vessel lesions in lamina propria n (%)

	n	Focal hemorrhage	Vessel inflammation	Fibroid necrosis	Thrombosis
Before treatment (mild)	56	41 (73.2)	27 (48.2)	1 (1.8)	0
After treatment (mild)	46	25 (54.3)	8 (17.4)	0	0
Before treatment (moderate)	50	32 (64.0)	34 (68.0)	2 (4.0)	1 (2.0)
After treatment (moderate)	45	22 (48.9)	12 (26.7)	0	0

Table 2 Effect of SASP on mucosal gland lesions n (%)

	n	Glandular abnormality	Epithelial cell regeneration	Atypical hyperplasia	GCD	PCM
Before treatment (mild)	56	17 (30.4)	19 (34.0)	8 (14.3)	3 (5.4)	0 (0)
After treatment (mild)	46	6 (13.0)	13 (28.3)	2 (4.4)	2 (4.4)	1 (2.2)
Before treatment (moderate)	50	21 (42.0)	15 (30.0)	15 (30.0)	12 (24)	2 (4.0)
After treatment (moderate)	45	18 (40.0)	7 (15.6)	8 (17.8)	6 (13.3)	0 (0)

Table 3 Effects of SASP on inflammatory cell infiltration n (%)

	n	Lymphocyte hyperplasia	Lymphoid follicle	Eos infiltration	Plasmacyte infiltration
Before treatment (mild)	56	42 (75.0)	44 (78.6)	55 (98.2)	50 (89.3)
After treatment (mild)	46	30 (65.2)	32 (69.6)	37 (80.4)	37 (80.4)
Before treatment (moderate)	50	37 (74.0)	35 (70.0)	50 (100)	46 (92)
After treatment (moderate)	45	32 (71.1)	26 (57.8)	41 (91.1)	39 (86.7)

Table 4 Effect of SASP on mucosal pathohistological grade (mean±SD)

	n	Mild	n	Moderate
Before treatment	46	2.00 ± 0.84	45	2.49 ± 0.84
After treatment	46	0.91 ± 0.46	45	1.31 ± 0.75