Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II

doi:10.3748/wjg.v11.i24.3671

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Jun 28, 2005 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2005; 11(24): 3671-3674
Published online Jun 28, 2005. doi: 10.3748/wjg.v11.i24.3671

Table 1 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by CCl₄ (mean±SD).

Group	Mice (n)	ALT (U/L)	AST (U/L)
Normal	10	47.68±15.23^b	130.10±74.17^b
Model control	10	511.86±255.86	562.93±183.84
Positive control	10	269.86±137.86^b	378.42±189.63^a
Picroside II (5 mg/kg)	10	404.15±21.10	416.28±230.48
Picroside II (10 mg/kg)	10	293.69±177.40^a	402.14±181.09^a
Picroside II (20 mg/kg)	10	242.01±163.96^b	277.46±84.64^b

^aP<0.05,

^bP<0.01 vs model control.

Table 2 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by AP (mean±SD).

Group	Mice (n)	ALT (U/L)	AST (U/L)
Normal	10	56.53±11.52^b	151.22±15.87^b
Model control	10	508.91±220.93	711.77±151.27
Positive control	10	328.67±143.06^a	335.84±257.02^b
Picroside II (5 mg/kg)	10	342.52±186.33	411.23±190.89^b
Picroside II (10 mg/kg)	10	225.89±75.28^b	318.17±161.20^b
Picroside II (20 mg/kg)	10	197.87±46.11^b	283.40±140.76^b

^aP<0.05,

^bP<0.01 vs model control.

Table 3 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by D-GalN (mean±SD).

Group	Mice (n)	ALT (U/L)	AST (U/L)
Normal	10	46.59±14.18^b	140.77±11.85^b
Model control	10	1 036.67±588.34	800.82±418.75
Positive control	10	548.32±254.35^a	502.42±192.43^a
Picroside II (5 mg/kg)	10	635.93±266.90^a	523.56±184.12
Picroside II (10 mg/kg)	10	495.3±260.70^a	491.90±116.35^a
Picroside II (20 mg/kg)	10	250.69±142.19^b	368.61±121.79^b

^aP<0.05,

^bP<0.01 vs model control.

Table 4 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by CCl₄ (mean±SD).

Group	M (n)	MDA (nmol/L)	SOD (NU/mL)	GSH-Px (mmol/g)
Normal	10	4.24±0.46^b	264.82±14.8^b	96.42±8.2^b
Model control	10	8.48±0.56	218.41±14.4	64.22±5.4
Positive control	10	5.46±1.06^b	244.54±12.6^a	80.63±7.2^b
Picroside II (5 mg/kg)	10	6.88±1.12^b	238.63±14.6^a	66.46±6.2
Picroside II (10 mg/kg)	10	5.22±0.38^b	250.22±15.2^b	70.82±8.4^a
Picroside II (20 mg/kg)	10	4.46±0.88^b	254.26±16.6^b	88.66±9.8^b

^aP<0.05,

^bP<0.01 vs model control.

Table 5 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by AP (mean±SD).

Group	M (n)	MDA (nmol/L)	SOD (NU/mL)	GSH-Px (mmol/g)
Normal	10	1.74±0.32^b	288.61±11.8^b	86.42±4.2^b
Model control	10	5.48±0.24	202.42±10.4	54.67±3.4
Positive control	10	2.46±0.36^b	236.35±14.6^b	70.63±3.2^a
Picroside II (5 mg/kg)	10	2.88±0.42^b	216.62±11.6^a	59.64±2.2
Picroside II (10 mg/kg)	10	2.24±0.28^b	250.21±15.2b	68.82±2.4^a
Picroside II (20 mg/kg)	10	2.02±0.12^b	278.23±14.2^b	81.62±6.8^b

^aP<0.05,

^bP<0.01 vs model control.

Table 6 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by D-GalN (mean±SD).

Group	M (n)	MDA (nmol/L)	SOD (NU/mL)	GSH-Px (mmol/g)
Normal	10	2.24±0.22^b	302.28±16.8^b	82.24±3.22^b
Model control	10	6.64±0.32	246.62±15.2	58.32±2.22
Positive control	10	3.48±0.16^b	284.25±12.2^b	72.28±3.01^a
Picroside II (5 mg/kg)	10	4.88±0.42^a	254.64±14.4	61.24±2.64
Picroside II (10 mg/kg)	10	3.22±0.26^b	268.28±14.2^a	70.26±2.86^a
Picroside II (20 mg/kg)	10	3.02±0.24^b	286.24±16.2^b	78.24±3.12^b

^aP<0.05,

^bP<0.01 vs model control.

Table 7 Effects of picroside II on activities of ATPase and swelling extent of mitochondria of mice with acute liver damage induced by AP (mean±SD).

Group	Mice (n)	Activities of ATPase mmol (pi)/(h·mg) (protein)	Swelling extent of mitochondria 0-5 min A₅₂₀	Swelling extent of mitochondria 5-10 min A₅₂₀
Normal	10	24.24±0.26^a	0.528±0.004^b	0.520±0.002^b
Model control	10	20.18±0.16	0.462±0.002	0.432±0.001
Positive control	10	23.48±0.16^a	0.495±0.001^b	0.476±0.001^a
Picroside II (5 mg/kg)	10	21.01±0.42	0.474±0.002	0.450±0.002^b
Picroside II (10 mg/kg)	10	23.22±0.26^a	0.496±0.001^a	0.484±0.002^a
Picroside II (20 mg/kg)	10	25.02±0.24^a	0.512±0.006^b	0.502±0.004^b

^aP<0.05,

^bP<0.01 vs model control.

Citation: Gao H, Zhou YW. Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. World J Gastroenterol 2005; 11(24): 3671-3674
URL: https://www.wjgnet.com/1007-9327/full/v11/i24/3671.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i24.3671