Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh’s esophageal squamous cell cancer in Xinjiang, China

Table 1 Genotypes of GSTM1 in controls and subjects with cancer n (%).

	GSTM1 (+)	GSTM1 (-)	OR (95%CI)
Control (n = 104)	100 (96.2)a	4 (3.8)	1.0
ESCC (n = 104)	68 (65.4)	36 (34.6)	13.24 (4.50-38.89)

^aP<0.05 vs ESCC group.

Table 2 Distribution of CYP2E1 genetic polymorphism in controls and subjects with cancer n (%).

	c1/c1	c1/c2+ c2/c2	OR (95%CI)
Control (n = 104)	25 (24.0)	79 (76.0)	1.0
ESCC (n = 104)	81 (77.9)a	23 (22.1)	11.13 (5.84-21.22)

^aP<0.05 vs control group.

Table 3 Distribution of CYP2E1 allele frequency in controls and subjects with cancer n (%).

	Allele c1	Allele c2	OR (95%CI)
Control (n = 104)	124 (59.6)	84 (40.4)	1.0
ESCC (n = 104)	182 (87.5)a	26 (12.5)	4.74 (2.89-7.78)

^aP<0.05 vs control group.

Table 4 Combinations of GSTM1 present and CYP2E1 genetic polymorphism in controls and subjects with cancer n (%).

	c1/c1	c1/c2 + c2/c2	OR (95%CI)
Control (n = 97)	19 (19.6)	78 (80.4)	1.0
ESCC (n = 68)	52 (76.5)a	16 (23.5)	13.34 (6.29-28.3)

^aP<0.05 vs control group.