Gene expression in Barrett’s esophagus and reflux esophagitis induced by gastroduodenoesophageal reflux in rats

Table 1 Some up or down-regulated genes expressed in Barrett’s esophagus compared to esophagitis.

Up-regulated gene

Glutathione synthetase

S100 calcium binding protein A9

alpha-fibrinogen

alpha-1-protease inhibitor

Lyn protein non-receptor kinase

Polymeric immunoglobulin receptor

Prostaglandin D2 synthase 2

Serine protease inhibitor

Kangai 1

Hemopexin

Fibrinogen

DOC-2 p82 isoform

Leukemia-associated cytosolic phosphoprotein

Junctional adhesion molecule 1

Interleukin 1 beta

Cell adhesion regulator

Table 2 Some genes expressed down-regulation in Barrett’s esophagus compared to esophagitis.

Down-regulated gene

BCL2/adenovirus E1B 19-ku-interacting protein-3

Transforming growth factor b stimulated clone-22

Tissue inhibitor of metalloproteinase-3

Phosphoglyceromutase

CD36 antigen

Calsequestrin 2

Transgelin

Mitochondrial adenine nucleotide translocator

Glucocorticoid-induced leucine zipper

Extracellular matrix protein 2

Protein tyrosine phosphatase

Table 3 Functional classification of genes expressed differently between Barrett’s esophagus and esophagitis epithelia.

Functional classification	n	Up-regulated	Down-regulated
Oncogenes and tumor suppressor genes	14	12	2
Ion channel and transporters	30	16	14
Cell cycle proteins	21	18	3
Extra-pressure reaction proteins	20	18	2
Cell regulatory proteins	13	9	4
Cell apoptosis related proteins	14	10	4
DNA synthesis, repair and recombinant factors	25	17	8
DNA binding, transcription factors	30	22	8
Cell receptors	33	27	8
Immunity-related proteins	29	17	12
Cell signal transduction proteins	40	27	13
Metabolism related proteins	31	21	10
Total	300	214	86