Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B

Table 1 Demographic features of the study and the control groups.

	Patients	Control
n	30	30
Sex
Male (%)	24 (80)	18 (60)
Female (%)	6 (20)	12 (40)
Age (yr)
Age interval	16-55	21-38
Median age	26	22

Table 2 Cytokine results of the study and control groups (mean±SD).

	Patients	Control	P
IFN-γ	1.57±0.59	3.44±0.41	<0.0001
IL-4	2.51±0.67	1.01±3.88	<0.030
TGF-β1	822.8±121.24	419.33±37.78	<0.002
TNF-α	17.7±4.98	3.1±1.21	<0.005

Table 3 NIA and fibrosis results of the patients.

Fibrosis	NIA				Total
	Minimal	Mild	Moderate	Severe
Absent	3	0	0	0	3
Mild	6	4	1	0	11
Severe	4	3	4	3	14
Cirrhosis	0	0	0	2	2
Total	13	7	5	5	30