Effects of rhubarb on isolated gastric muscle strips of guinea pigs

Table 1 Effect of rhubarb and antagonists plus rhubarb on the resting tension of gastric body CM of guinea pigs (mean±SE, n = 12).

Group	0	1%	3%	10%	30%	100%
Rhubarb	1.00	1.04±0.02a	1.15±0.05a	1.42±0.08b	1.75±0.08b	1.88±0.08b
Atropine (10-6 mol/L)+rhubarb	1.00	1.00c	1.02±0.01c	1.08±0.02bd	1.19±0.03bd	1.43±0.06bd
Isoptin (5×10-8 mol/L)+rhubarb	1.00	1.01±0.01	1.03±0.02	1.09±0.04ad	1.23±0.05bd	1.42±0.06bd
Hexamethonium (10-5mol/L)+rhubarb	1.00	1.00c	1.05±0.02a	1.10±0.02bd	1.24±0.05bd	1.39±0.04bd

^aP<0.05,

^bP<0.01 vs control;

^cP<0.05,

^dP<0.01 vs rhubarb in the same concentration.

Table 2 Effect of rhubarb and antagonists plus rhubarb on the contractile frequency of gastric body CM of guinea pigs (mean±SE, n = 12).

Group	0	1%	3%	10%	30%	100%
Rhubarb	5.40±0.08	5.48±0.10	5.45±0.09	5.61±0.11a	5.60±0.09a	5.73±0.10b
Atropine (10-6 mol/L)+rhubarb	5.40±0.10	5.43±0.12	5.42±0.12	5.46±0.15	5.53±0.16	5.59±0.12
Isoptin (5×10-8 mol/L)+rhubarb	5.35±0.11	5.32±0.10	5.38±0.09	5.36±0.10	5.47±0.09	5.63±0.17a
Hexamethonium (10-5 mol/L)+rhubarb	5.43±0.05	5.48±0.04	5.48±0.05	5.48±0.04	5.53±0.04a	5.61±0.06a

^aP<0.05, ^bP<0.01 vs control.

Table 3 Effect of rhubarb and antagonists plus rhubarb on the mean contractile amplitude of gastric body CM of guinea pigs (mean±SE, n = 12).

Group	0	1%	3%	10%	30%	100%
Rhubarb	0.59±0.10	0.59±0.11	0.64±0.11	0.51±0.09	0.47±0.10	0.36±0.07b
Atropine (10-6 mol/L)+rhubarb	0.57±0.10	0.55±0.10	0.51±0.09a	0.48±0.10a	0.44±0.10a	0.33±0.07a
Isoptin (5×10-8 mol/L)+rhubarb	0.59±0.09	0.53±0.08	0.49±0.07b	0.44±0.07a	0.56±0.12	0.53±0.10
Hexamethonium (10-5 mol/L)+rhubarb	0.59±0.12	0.55±0.12a	0.54±0.11a	0.52±0.11a	0.48±0.10a	0.42±0.09a

^aP<0.05,

^bP<0.01 vs control.