Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival

Table 1 iNOS expression and clinicopathologic features in gastric adenocarcinoma.

Variable	Definition	Intermediate	Negative or high n (%)	P or low n (%)
Age (yr)	≤59 yr	22 (53.66)	14 (56)	0.853
	≥60 yr	19 (46.34)	11 (44)
Gender	Female	20 (48.78)	10 (40)	0.487
	Male	21 (51.22)	15 (60)
Tumor size	<5 cm	12 (29.27)	15 (60)	0.014
	≥5 cm	29 (70.73)	10 (40)
Borrmann classification	0, 1, 2	20 (48.78)	12 (48)	0.951
	3, 4	21 (51.22)	13 (52)
Depth of invasion pT1,	2	11 (26.83)	13 (52)	0.039
	pT3, 4	30 (73.17)	12 (48)
Lymph node metastasis	Negative	13 (31.71)	15 (60)	0.024
	Positive	28 (68.29)	10 (40)
Lauren's classification	Intestinal	15 (36.59)	12 (48)	0.360
	Diffuse	26 (63.41)	13 (52)
Degree of differentiation	Well and moderate	19 (46.34)	11 (44)	0.853
	Poor	22 (53.66)	14 (56)
TNM staging	III, IV	10 (24.39)	12 (48)	0.048
	I, II	31 (75.61)	13 (52)

Table 2 Univariate and multivariate regression analyses of prognostic indicators for long-term survival.

Factor	Categories	Univariate	Multivariate
		P (Log-rank test)	P (Wald test)	RR (95%CI)
iNOS expression	≥5 scores	0.001	0.012	2.69 (1.54.8)
	≤4 scores
Depth of invasion	pT3, 4	<0.001	0.020	4.11 (1.54.7)
	pT1, 2
Lymph node metastasis	Positive	<0.001	<0.001	5.77 (2.06.6)
	Negative
TNM staging	III, IV	<0.001	0.007	3.94 (1.47.2)
	I, II
Tumor size	≥5 cm	0.043	NS
	<5 cm
Lauren's classification	Diffuse	0.032	NS
	Intestinal
Borrmann classification	3, 4	0.026	NS
	0, 1, 2
Degree of differentiation	Poor	0.023	NS
	Well and moderate
Age (yr)	≤59	0.178
	≥60
Gender	Female	0.201
	Male

≥5 scores: intermediate or high iNOS expression; ≤4 scores: negative or low iNOS expression; RR: relative risk; CI: confidence interval; NS, not significant.