Relationships of tumor inflammatory infiltration and necrosis with microsatellite instability in colorectal cancers

Table 1 Relationship of tumor inflammatory infiltration and necrosis with microsatellite status.

Variable Category	Microsatellite stability (%)	Microsatellite instability (%)	P
Infiltration at the invasive margin			0.047
Low	120 (79)	24 (96)
High	31 (21)	1 (4)
Infiltration in the tumor			0.049
Low	71 (46)	17 (68)
High	81 (54)	8 (32)
Necrosis			0.75
Little	76 (51)	13 (54)
Abundant	74 (49)	11 (46)

Table 2 Relationship of tumor inflammatory infiltration at the invasive margin and TN with clinicopathological and other variables.

Variable	Category	Inflammatory infiltration at the invasive margin			TN
		n	High (%)	P	n	Abundant	P
Gender				0.06			0.31
	Male	158	27 (17)		158	85 (54)
	Female	143	37 (26)		142	68 (48)
Age (yr)				0.68			0.12
	≤70	138	31 (22)		138	77 (56)
	>70	161	33 (21)		160	75 (47)
Tumor location				0.55			0.75
	Proximal	109	25 (23)		108	54 (50)
	Distal	185	37 (20)		185	96 (52)
Dukes stage				0.03			0.001
	A	47	11 (23)		45	15 (33)
	B	102	26 (25)		103	45 (44)
	C	94	23 (24)		94	53 (56)
	D	50	3 (6)		50	36 (72)
Gowth pattern				0.65			0.38
	Expansive	128	25 (20)		128	64 (50)
	Infiltration	152	33 (22)		152	84 (55)
Differentiation				0.03			<0.0001
	Well	23	10 (43)		24	7 (29)
	Moderately	196	42 (21)		195	116 (60)
	Poorly	44	7 (16)		43	22 (51)
	Mucinous+signet-ring cell	37	5 (14)		37	8 (22)
DNA ploidy				0.002			0.14
	Diploid	107	32 (30)		107	53 (49)
	Non-diploid	118	15 (13)		118	70 (59)
S-phase fraction				0.004			0.24
	<5%	52	19 (37)		52	26 (50)
	5-10%	65	16 (25)		65	31 (48)
	>10%	72	8 (11)		72	44 (61)
p53 expression				0.01			0.07
	Negative	117	33 (28)		117	57 (49)
	Positive	114	15 (13)		114	69 (61)