Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis

doi:10.3748/wjg.v11.i14.2109

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World Journal of Gastroenterology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2005; 11(14): 2109-2116
Published online Apr 14, 2005. doi: 10.3748/wjg.v11.i14.2109

Table 1 The top 10 highly expressed genes in normal gallbladder tissue.

Name of gene	Symbol	Gray level (mean±SD)
Breakpoint cluster region protein, uterine leiomyoma, 2	BCRP2	2738.74±23.23
Actin-related protein 2/3 complex, subunit 5 (16 ku)	ARPC5	2225.88±90.46
Eukaryotic translation initiation factor 4A, isoform 1	EIF4A1	2223.86±274.74
Mitochondrial carrier family protein	LOC55972	2220.32±446.51
Solute carrier family 20 (phosphate transporter), member 2	SLC20A2	1865.21±98.02
Cytochrome b5 reductase 1 (B5R.1)	LOC51706	1851.01±298.45
ADP-ribosylation factor 1	ARF1	1844.63±353.31
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	FARP1	1654.95±126.85
Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	PSME2	1635.33±148.15
cAMP responsive element binding protein-like 1	CREBL1	1579.36±71.68

Table 2 Lipid-related genes expressed in normal gallbladder.

GenBank ID	Gene name	Symbol	Reported or not	Gray level (mean±SD)
NM_000859	3-Hydroxy-3-methylglutaryl-Coenzyme A reductase²	HMGCR	P³	10.98±0.31
U66669	3-hydroxyisobutyryl-Coenzyme A hydrolase	HIBCH		11.17±0.09
U29344	Fatty acid synthase	FASN		11.42±2.62
AA460901	ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2	ATP8A2		11.53±1.08
BE730527	Lipase protein	LOC57406	P³	11.58±0.85
AL043165	Homolog of mouse transient receptor potential-phospholipase; C-interacting kinase CHaK; hypothetical protein FLJ20117	LTRPC7		11.59±0.69
U22662	Nuclear receptor subfamily 1, group H, member 3²	NR1H3		11.77±0.85
M14564	Cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia	CYP17		12.06±1.35
M93107	3-Hydroxybutyrate dehydrogenase (heart, mitochondria)	BDH	P³	12.10±2.22
NM_019844	Solute carrier family 21 (organic anion transporter), member 8²	SLC21A8	P³	12.14±0.77
AK000184	Acid sphingomyelinase-like phosphodiesterase	ASM3A		12.22±0.65
±X04506	±Apolipoprotein B (including Ag(x) antigen)	APOB	U¹	12.23±1.17
X87176	Hydroxysteroid (17-beta) dehydrogenase 4	HSD17B4	U¹	12.25±0.57
AF095703	L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain	HADHSC		12.37±1.66
AW022180	ESTs, weakly similar to S14747 sphingomyelin phosphodiesterase [H. sapiens]			12.39±2.40
U32576	Apolipoprotein C-IV	APOC4	U¹	12.58±0.28
AI133376	Human DNA sequence from clone RP11-16L21 on chromosome 9. Contains the gene for NADP-dependent leukotriene B4 12-hydroxydehydrogenase, the gene for a novel DnaJ domain protein similar to Drosophila, C. elegans and Arabidopsis predicted proteins, the GNG10			12.75±1.64
AV658073	Homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK	hypothetical protein FLJ20117	LTRPC7	12.83±1.45
X03635	Estrogen receptor 1	ESR1		12.83±0.34
AF165514	Hydroxysteroid (17-beta) dehydrogenase 7	HSD17B7	P³	12.99±0.56
NM_018557	Low density lipoprotein-related protein 1B (deleted in tumors)	LRP1B		13.06±0.29
U22526	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	LSS		13.14±0.70
X83618	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)	HMGCS2	P³	13.34±0.03
D14662	Anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2)	KIAA0106	U¹	13.40±0.78
M62839	Apolipoprotein H (beta-2-glycoprotein I)	APOH		13.49±0.20
Z99716	Sterol regulatory element binding transcription factor 2²	SREBF2	P³	13.53±2.31
AF126799	Fatty acid desaturase 2	FADS2		13.62±2.16
AV662152	EST, moderately similar to LPHUC1 apolipoprotein C-I precursor [H. sapiens]			13.63±1.57
M37238	Phospholipase C, gamma 2 (phosphatidylinositol-specific)	PLCG2	P³	13.79±2.16
AF129756	Apolipoprotein M G3A			13.90±0.29
AW873435	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		13.98±1.71
U09117	Phospholipase C, delta 1	PLCD1	P³	14.06±0.58
AC007954	Glutathione transferase zeta 1 (maleylacetoacetate isomerase)	GSTZ1		14.13±0.76
AA706930	Fatty acid binding protein 1, liver	FABP1	U¹	14.19±0.25
AB011153	Phosphoinositide-specific phospholipase C-beta 1	PLCB1		14.65±2.22
AF038440	Phospholipase D2	PLD2		14.66±5.01
N42553	Homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK	hypothetical protein FLJ20117	LTRPC7	14.68±2.50
AL110209	LCAT-like lysophospholipase		LLPL	14.88±2.24
X13916	Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)²	LRP1		14.91±1.56
AI955289	ESTs, weakly similar to DXHUBH 11beta-hydroxysteroid dehydrogenase [H.sapiens]			14.96±1.66
AF077046	Ganglioside expression factor 2	GEF-2		15.11±1.98
Z34975	Low density lipoprotein receptor defect C complementing	LDLC		15.18±2.11
BE271295	Group XII secreted phospholipase A2	PLA2G12		15.64±1.27
U49248	ATP-binding cassette, sub-family C (CFTR/MRP), member 2²	ABCC2	U¹	15.78±0.45
N78156	Homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2	HELO1		15.95±5.40
AB016247	Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like	SC5DL	P³	16.09±3.33
NM_000954	Prostaglandin D2 synthase (21 ku, brain)	PTGDS		16.19±3.18
U60205	Sterol-C4-methyl oxidase-like	SC4MOL		16.22±1.29
AA557324	ESTs, weakly similar to fatty acid omega-hydroxylase [H.sapiens]			16.31±2.98
X66435	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P³	16.46±2.32
AL117352	Human DNA sequence from clone RP5-876B10 on chromosome 1q42.12-43. Contains the 3' end of the GNPAT gene for glyceronephosphate O-acyltransferase (DHAPAT, DAPAT, dihydroxyacetone phosphate acyltransferase, EC 2.3.1.42), the gene for a novel protein (ortho)			16.74±0.16
BE737965	Caveolin 1, caveolae protein, 22 ku²	CAV1		16.74±2.50

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.

Table 3 Lipid-related genes expressed in normal gallbladder.

U68233	Nuclear receptor subfamily 1, group H, member 4^**	NR1H4		16.80±0.65
AF035284	Fatty acid desaturase 1	FADS1	U¹	16.82±0.92
X04898	Apolipoprotein A-II	APOA2	U¹	16.96±2.01
AL031295	Lysophospholipase II	LYPLA2	P³	17.01±0.19
AL031295	3-Hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)	HMGCL		17.01±0.19
M55150	Fumarylacetoacetate hydrolase (fumarylacetoacetase)	FAH		17.41±2.04
M31210	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1	EDG1		17.56±0.62
BE395256	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	LSS		17.63±1.71
NM_000483	Apolipoprotein C-II	APOC2	U¹	17.71±1.70
L76465	Hydroxyprostaglandin dehydrogenase 15-(NAD)	HPGD		17.86±0.79
S68287	Aldo-keto reductase family 1, member C4 (chlordecone reductase 3-alpha hydroxysteroid dehydrogenase, type I dihydrodiol dehydrogenase 4)	AKR1C4	P³	18.11±2.89
M54927	Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)	PLP1	P³	18.21±1.67
BE714757	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		18.26±2.02
AJ238243	Phospholipase A2-activating protein	PLAA		18.73±3.07
AF077820	Low density lipoprotein receptor-related protein 5	LRP5		18.98±2.79
AL031778	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	APOBEC2	P³	19.21±3.45
AC004770	Fatty acid desaturase 1	FADS1	U¹	19.22±9.65
AC004770	Fatty acid desaturase 3	FADS3		19.22±9.65
AA280051	Fatty acid binding protein 1, liver	FABP1	U¹	19.81±3.80
X67698	Niemann–Pick disease, type C2 gene	NPC2		20.53±1.84
AL049748	Apolipoprotein L, 5	APOL5		20.61±0.01
X51416	Estrogen-related receptor alpha	ESRRA		20.63±1.82
AF065215	Phospholipase A2, group IVB (cytosolic)	PLA2G4B	P³	20.71±3.25
AB006746	Phospholipid scramblase 1	PLSCR1	U¹	21.33±0.62
M59979	Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	PTGS1	P³	21.55±0.74
X02162	Apolipoprotein A-I	APOA1	U¹	21.70±0.75
AF079167	Oxidised low density lipoprotein (lectin-like) receptor 1	OLR1	P³	22.12±7.75
U55764	Sulfotransferase, estrogen-preferring	STE		22.15±2.72
J03459	Leukotriene A4 hydrolase	LTA4H		22.32±4.28
U03090	Phospholipase A2, group V	PLA2G5	P³	22.88±2.74
M76665	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1	P³	22.98±3.71
NM_016108	Androgen induced protein	AIG-1	P³	23.02±3.33
AV651650	ESTs, highly similar to AF237982 1 oxysterol 7 alpha-hydroxylase [H.sapiens]			23.62±0.57
U11313	Sterol carrier protein 2²	SCP2	U¹	23.92±0.18
NM_001645	Apolipoprotein C-I	APOC1	U¹	25.02±12.59
X54741	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2	CYP11B2		25.13±3.81
X01388	Apolipoprotein C-III	APOC3		25.17±4.82
R98624	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P³	25.26±16.74
U93305	Proteolipid protein 2 (colonic epithelium-enriched)	PLP2	P³	25.41±2.44
U67963	Lysophospholipase-like	HU-K5		26.75±5.28
D86096	Prostaglandin E receptor 3 (subtype EP3)	PTGER3	P³	26.79±0.19
AL022398	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1		26.82±8.70
X76488	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		27.10±11.84
AF019225	Apolipoprotein L	APOL1	U¹	28.12±1.76
AL034374	Homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2	HELO1		28.76±4.09
AI675602	EST, moderately similar to I65981 fatty acid omega-hydroxylase [H.sapiens]			28.85±13.77
U89281	Oxidative 3 alpha hydroxysteroid dehydrogenase; retinol dehydrogenase; 3-hydroxysteroid epimerase	RODH		29.09±7.19
AL022318	Phorbolin (similar to apolipoprotein B mRNA editing protein)	DJ742C19.2		29.26±5.26
X07228	Lipase, hepatic	LIPC	P³	30.57±4.34
AL031230	Glycosylphosphatidylinositol specific phospholipase D1	GPLD1		30.88±1.21
AA128778	Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	TFPI		32.76±0.09
Z99390	L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain	HADHSC		33.87±0.98
AF002020	Niemann–Pick disease, type C1²	NPC1		34.88±12.12
X55764	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1	CYP11B1		34.95±1.61
L34081	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P³	37.8±3.91
AF002668	Degenerative spermatocyte (homolog Drosophila lipid desaturase)	DEGS		37.93±4.50
AF034544	7-Dehydrocholesterol reductase	DHCR7		38.05±2.80
D82073	Prostaglandin D2 synthase, hematopoietic	PGDS		38.83±13.58
Z37986	Emopamil-binding protein (sterol isomerase)	EBP		41.25±12.24
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1	SOAT1	P³	44.08±1.76
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1²	SOAT1	P³	44.08±1.76

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.

Table 4 Lipid-related genes expressed in normal gallbladder.

U68233	Nuclear receptor subfamily 1, group H, member 4^**	NR1H4		16.80±0.65
AF035284	Fatty acid desaturase 1	FADS1	U¹	16.82±0.92
X04898	Apolipoprotein A-II	APOA2	U¹	16.96±2.01
AL031295	Lysophospholipase II	LYPLA2	P³	17.01±0.19
AL031295	3-Hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)	HMGCL		17.01±0.19
M55150	Fumarylacetoacetate hydrolase (fumarylacetoacetase)	FAH		17.41±2.04
M31210	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1	EDG1		17.56±0.62
BE395256	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	LSS		17.63±1.71
NM_000483	Apolipoprotein C-II	APOC2	U¹	17.71±1.70
L76465	Hydroxyprostaglandin dehydrogenase 15-(NAD)	HPGD		17.86±0.79
S68287	Aldo-keto reductase family 1, member C4 (chlordecone reductase 3-alpha hydroxysteroid dehydrogenase, type I dihydrodiol dehydrogenase 4)	AKR1C4	P³	18.11±2.89
M54927	Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)	PLP1	P³	18.21±1.67
BE714757	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		18.26±2.02
AJ238243	Phospholipase A2-activating protein	PLAA		18.73±3.07
AF077820	Low density lipoprotein receptor-related protein 5	LRP5		18.98±2.79
AL031778	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	APOBEC2	P³	19.21±3.45
AC004770	Fatty acid desaturase 1	FADS1	U¹	19.22±9.65
AC004770	Fatty acid desaturase 3	FADS3		19.22±9.65
AA280051	Fatty acid binding protein 1, liver	FABP1	U¹	19.81±3.80
X67698	Niemann–Pick disease, type C2 gene	NPC2		20.53±1.84
AL049748	Apolipoprotein L, 5	APOL5		20.61±0.01
X51416	Estrogen-related receptor alpha	ESRRA		20.63±1.82
AF065215	Phospholipase A2, group IVB (cytosolic)	PLA2G4B	P³	20.71±3.25
AB006746	Phospholipid scramblase 1	PLSCR1	U¹	21.33±0.62
M59979	Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	PTGS1	P³	21.55±0.74
X02162	Apolipoprotein A-I	APOA1	U¹	21.70±0.75
AF079167	Oxidised low density lipoprotein (lectin-like) receptor 1	OLR1	P³	22.12±7.75
U55764	Sulfotransferase, estrogen-preferring	STE		22.15±2.72
J03459	Leukotriene A4 hydrolase	LTA4H		22.32±4.28
U03090	Phospholipase A2, group V	PLA2G5	P³	22.88±2.74
M76665	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1	P³	22.98±3.71
NM_016108	Androgen induced protein	AIG-1	P³	23.02±3.33
AV651650	ESTs, highly similar to AF237982 1 oxysterol 7 alpha-hydroxylase [H.sapiens]			23.62±0.57
U11313	Sterol carrier protein 2²	SCP2	U¹	23.92±0.18
NM_001645	Apolipoprotein C-I	APOC1	U¹	25.02±12.59
X54741	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2	CYP11B2		25.13±3.81
X01388	Apolipoprotein C-III	APOC3		25.17±4.82
R98624	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P³	25.26±16.74
U93305	Proteolipid protein 2 (colonic epithelium-enriched)	PLP2	P³	25.41±2.44
U67963	Lysophospholipase-like	HU-K5		26.75±5.28
D86096	Prostaglandin E receptor 3 (subtype EP3)	PTGER3	P³	26.79±0.19
AL022398	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1		26.82±8.70
X76488	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		27.10±11.84
AF019225	Apolipoprotein L	APOL1	U¹	28.12±1.76
AL034374	Homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2	HELO1		28.76±4.09
AI675602	EST, moderately similar to I65981 fatty acid omega-hydroxylase [H.sapiens]			28.85±13.77
U89281	Oxidative 3 alpha hydroxysteroid dehydrogenase; retinol dehydrogenase; 3-hydroxysteroid epimerase	RODH		29.09±7.19
AL022318	Phorbolin (similar to apolipoprotein B mRNA editing protein)	DJ742C19.2		29.26±5.26
X07228	Lipase, hepatic	LIPC	P³	30.57±4.34
AL031230	Glycosylphosphatidylinositol specific phospholipase D1	GPLD1		30.88±1.21
AA128778	Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	TFPI		32.76±0.09
Z99390	L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain	HADHSC		33.87±0.98
AF002020	Niemann–Pick disease, type C1²	NPC1		34.88±12.12
X55764	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1	CYP11B1		34.95±1.61
L34081	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P³	37.8±3.91
AF002668	Degenerative spermatocyte (homolog Drosophila lipid desaturase)	DEGS		37.93±4.50
AF034544	7-Dehydrocholesterol reductase	DHCR7		38.05±2.80
D82073	Prostaglandin D2 synthase, hematopoietic	PGDS		38.83±13.58
Z37986	Emopamil-binding protein (sterol isomerase)	EBP		41.25±12.24
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1	SOAT1	P³	44.08±1.76
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1²	SOAT1	P³	44.08±1.76

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.

Table 5 Lipid-related genes expressed in normal gallbladder.

M12792	Cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2	CYP21A2		44.19±7.57
L07077	Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	EHHADH		45.78±6.21
BE566894	Human DNA sequence from clone RP11-16L21 on chromosome 9. Contains the gene for NADP-dependent leukotriene B4 12-hydroxydehydrogenase, the gene for a novel DnaJ domain protein similar to Drosophila, C. elegans and Arabidopsis predicted proteins, the GNG10		U¹	47.45±1.75
NM_016371	Hydroxysteroid (17-beta) dehydrogenase 7	HSD17B7		48.38±6.73
AF151638	Phosphatidylcholine transfer protein²	PCTP	P³	53.38±6.96
M12529	Apolipoprotein E²	APOE	P³	53.51±9.77
AL034369	Human DNA sequence from clone 149D17 on chromosome Xq22.2-23. Contains part of a PLRP2 (PNLIPRP2, pancreatic lipase-related protein 2 Precursor, EC 3.1.1.3) LIKE gene and 5' exons of the COL4A5 and alternatively spliced COL4A6 genes for Collagen, type IV			54.46±5.61
M22430	Phospholipase A2, group IIA (platelets, synovial fluid)	PLA2G2A	P³	58.57±9.02
AK000339	Long-chain fatty acid Coenzyme A ligase 5	FACL5	U¹	58.82±3.86
NM_013389	NPC1 (Niemann–Pick disease, type C1, gene)-like 1	NPC1L1	U¹	59.9±13.58
M63959	Low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)²	LRPAP1	U¹	60.24±6.70
AF263613	Intracellular membrane-associated calcium-independent phospholipase A2 gamma	IPLA2(GAMMA)		60.96±13.23
Z29481	3-Hydroxyanthranilate 3,4-dioxygenase	HAAO		62.47±0.09
D38081	Thromboxane A2 receptor	TBXA2R		66.03±19.67
X71973	Glutathione peroxidase 4 (phospholipid hydroperoxidase)	GPX4		69.27±12.44
AW662196	Apolipoprotein L, 2	APOL2	P³	79.49±5.89
AI590076	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P³	83.08±4.33
AL022398	Homo sapiens DNA sequence from PAC 434O14 on chromosome 1q32.3.-41. Contains the HSD11B1 gene for hydroxysteroid (11-beta) dehydrogenase 1, the ADORA2BP adenosine A2b receptor LIKE pseudogene, the IRF6 gene for Interferon Regulatory Factor 6 and two novel			85.30±14.15
AL022394	Phospholipase C, gamma 1 (formerly subtype 148)	PLCG1	P³	85.54±21.21
Z82215	Apolipoprotein L	APOL1	U¹	89.89±16.36
J02611	Apolipoprotein D	APOD		92.61±8.90
U19487	Prostaglandin E receptor 2 (subtype EP2), 53 ku	PTGER2	P³	95.40±18.27
X59812	Cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1²	CYP27A1	P³	100.70±10.81
AF070675	Apolipoprotein L, 3	APOL3	U¹	105.58±12.73
U00968	Sterol regulatory element binding transcription factor 1²	SREBF1	P³	107.4±8.65
AB018580	Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid	AKR1C3 dehydrogenase, type II)²	P³	110.69±31.00
X98332	Solute carrier family 22 (organic cation transporter), member 1²	SLC22A1	P³	112.02±22.09
M10617	Fatty acid binding protein 1, liver²	FABP1	U¹	117.5±11.59
L11702	Glycosylphosphatidylinositol specific phospholipase D1	GPLD1		149.16±33.78
X06290	Lipoprotein, Lp(a)	LPA	P³	156.94±26.59
X14723	Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)	CLU	U¹	163.92±11.19
BE018577	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P³	169.72±16.05
U23942	Cytochrome P450, 51 (lanosterol 14-alpha-demethylase)	CYP51		219.74±47.13
AL049547	Cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2	CYP21A2		246.11±42.36
AF081281	Lysophospholipase I	LYPLA1	P³	348.56±34.15
L40802	Hydroxysteroid (17-beta) dehydrogenase 2	HSD17B2		396.94±5.65

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.

Citation: Yuan ZB, Han TQ, Jiang ZY, Fei J, Zhang Y, Qin J, Tian ZJ, Shang J, Jiang ZH, Cai XX, Jiang Y, Zhang SD, Jin G. Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis. World J Gastroenterol 2005; 11(14): 2109-2116
URL: https://www.wjgnet.com/1007-9327/full/v11/i14/2109.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i14.2109