Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma

Table 1 Baseline characteristics of the two groups (mean±SD).

Parameters	H pylori positive (n = 42)	H pylori negative (n = 47)
Age (yr)	52.7±16.9	53.4±14.3
Sex (Male:Female)	20:22	24:2±3:00
Alcohol intake	20	21
Smoking habit	18	21
Body mass index	23.1±3.3	22.8±3.2

Table 2 Plasma concentrations of various peptides with respect to H pylori (mean±SD).

Peptide	H pylori positive (n = 42)	H pylori negative (n = 47)	P
Ghrelin (fmol/mL)	194.2±90.2	250.4±84.1	<0.05
Gastrin (pg/mL)	133.5±309.1	66.7±130.2	<0.005
Somatostatin (pg/mL)	11.3±5.7	9.7±6.2	Not significant
Leptin (ng/mL)	5.2±3.9	4.6±2.9	Not significant
Insulin-like growth factor 1 (ng/mL)	176.1±71.6	204.3±61.9	Not significant
Chromogranin A (ng/mL)	21.4±29.0	13.8±7.2	Not significant

Student’s t-test was employed in statistical analyses.

Table 3 Correlations of ghrelin with other peptides in plasma in terms of H pylori status.

	Gastrin	Somatostatin	Leptin	IGF-1	Chromogranin A
H pylori positive	0.015 (NS)	0.076 (NS)	-0.239 (NS)	0.064 (NS)	0.285 (P<0.05)
H pylori negative	0.025 (NS)	0.100 (NS)	-0.353 (P<0.05)	0.272 (P<0.05)	0.073 (NS)
Total	0.018 (NS)	0.086 (NS)	-0.318 (P<0.05)	0.097 (NS)	0.200 (NS)

Data are correlation coefficients and (P values) of the correlations. IGF-1: insulin-like growth factor-1, NS: not significant.