Effects of folic acid on epithelial apoptosis and expression of Bcl-2 and p53 in premalignant gastric lesions

Table 1 Changes in the gastric mucosal folate concentrations after folate treatment.

Group	n	Pre-T	Post-T
Treatment	19	7.16±1.88	9.03±3.37b
Control	19	6.90±2.72	6.83±3.02

n: number; Treatment: treatment group; Control: control group; Pre-T: before treatment; Post-T: after treatment; Data are shown as (mean±SD) μg/g wet wt.

^bP<0.01 vs control group and before treatment in the same group.

Table 2 Effects of folic acid on the apoptosis rate in gastric epithelial cells.

Group	n	Staining with PI (%)		Staining with annexin V FITC/PI (%)
		Pre-T	Post-T	Pre-T	Post-T
Treatment	19	6.19±2.82	6.78±2.15b	16.22±3.80	21.00±4.61a
Control	19	6.27±3.24	6.23±2.70	15.10±2.52	15.70±2.56

Apoptosis rate represents the ratio of Annexin V+/PI- cells to the total cell population. n: number; Treatment: treatment group; Control: control group; Pre-T: before treatment; Post-T: after treatment; Data are shown as (mean±SD)%.

^aP<0.05 and

^bP<0.01 vs control group and before treatment in the same group.

Table 3 Effects of folic acid on the expression of Bcl-2 and p53 in gastric epithelial cells.

Group	n	Bcl-2 expression		p53 expression
		Pre-T	Post-T	Pre-T	Post-T
Treatment	19	8.17±2.06	6.22±1.26a	2.03±0.35	2.56±0.47b
Control	19	6.78±2.57	6.98±2.55	1.75±0.65	1.70±0.39

n: number; Treatment: treatment group; Control: control group; Pre-T: before treatment; Post-T: after treatment; Data are shown as (mean±SD)%.

^aP<0.05 and

^bP<0.01 vs control group and before treatment in the same group.