Effects of autoantibodies against &beta;1-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca2+ currents

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Apr 15, 2004 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Apr 15, 2004; 10(8): 1171-1175
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1171

Table 1 Effects of anti-β₁-receptor autoantibodies diluted at 1:80 on action potential phases (n = 6)

	Control	Anti-β₁-receptor autoantibodies
APD₂₀(mV)	67.3 ± 1.8	93.7 ± 3.6^b
APD₅₀(mV)	148.8 ± 5.4	192.1 ± 6.7^b
APD₉₀(mV)	195.6 ± 8.2	225.3 ± 11.5^b

^bP < 0.01 vs control.

Table 2 Effects of anti-β₁-receptor autoantibodies diluted at 1:80 on action potential phases in the presence of 1 μmol/L metoprolol (n = 6)

	Control	Anti-β₁-receptor autoantibodies and metoprolol
APD₂₀ (mV)	65.8 ± 1.1	70.5 ± 2.3
APD₅₀ (mV)	147.2 ± 4.6	155.0 ± 6.3
APD₉₀ (mV)	196.2 ± 5.1	204.3 ± 9.4

Citation: Liu K, Liao YH, Wang ZH, Li SL, Wang M, Zeng LL, Tang M. Effects of autoantibodies against β₁-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca²⁺ currents. World J Gastroenterol 2004; 10(8): 1171-1175
URL: https://www.wjgnet.com/1007-9327/full/v10/i8/1171.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i8.1171