Expression of p21WAF1 and p53 and polymorphism of p21WAF1 gene in gastric carcinoma

Table 1 Expression of p21 and p53 proteins in normal gastric mucosa, dysplasia and gastric carcinoma

Tissue type	Cases number	p21					p53
		Negativity (%)	Positivity (%)				Negativity (%)	Positivity (%)
			+	++	+++	total		+	++	+++	total
NGM	20	0(0)	6	7	7	20 (100)	20 (100)	0	0	0	0 (0)
DP	40	3(7.5)	8	11	18	37 (92.5)	34 (85.0)	1	3	2	6 (15.0)
GC	108	65(60.2)	9	14	20	43 (39.8)	47 (43.5)	17	19	25	61 (56.5)

NGM: normal gastric mucosa; DP: dysplasia; GC: gastric carcinoma.

Table 2 Association of p21 and p53 expression with clinico-pathologic parameters in gastric carcinoma

Parameters	Cases (n)	p21 positivity (%)	p53 positivity (%)
Age
≤ 50	43	18 (41.9)	25 (58.1)
51-59	37	15 (40.5)	20 (54.1)
≥ 60	28	10 (35.7)	16 (57.1)
Sex
Male	81	32 (39.5)	43 (53.1)
Female	27	11 (40.7)	18 (66.7)
Grade
Well-differentiated	30	19 (63.3)	11 (36.7)
Poorly-differentiated	40	14 (35.0)	31 (77.5)
Undifferentiated	15	4 (26.7)	12 (80)
Mucoid	13	4 (30.8)	4 (30.8)
Signet ring cell	10	2 (20.0)	3 (30)
Invasion depth
Superficial muscle	20	12 (60.0)	11 (55)
Total layer	88	31 (35.2)	50 (56.8)
Lymph node metastasis
Absence	40	25 (62.5)	17 (42.5)
Presence	68	24 (35.3)	48 (70.6)
TNM stage
I	15	9 (60.0)	7 (46.7)
II	32	18 (56.2)	17 (53.1)
III	43	12 (27.9)	26 (60.5)
IV	18	4 (22.2)	11 (61.1)

Table 3 Relationship between expression of p21 and p53 in gastric carcinoma and dysplasia

p21	p53
	Positive (%)	Negative (%)	Total (%)
Dysplasia
Positive	4 (10.0)	33 (82.5)	37 (92.5)
Negative	2 (5.0)	1 (2.5)	3 (7.5)
Total	6 (15.0)	34 (85.0)	40 (100)
Gastric carcinoma
Positive	26 (24.1)	17 (15.7)	43 (39.8)
Negative	35 (32.4)	30 (27.8)	65 (60.2)
Total	61 (56.5)	47 (43.5)	108 (100)