Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation

Table 1 Summary of immunohistochemical analysis of MRP8 and MRP14 in esophageal epithelium and tumors. (Fisher’s exact test)

ExpressionLevel1	MRP8			MRP14
	Normal (%)	Tumors (%)	P-value	Normal (%)	Tumors (%)	P-value
3+	29(44.6)	14(21.5)	< 0.01b	60(92.3)	24(36.9) < 0.01d
2+	32(49.2)	29(44.6)		3(4.6)	21(32.3)
1+	0(0)	6(9.2)		0(0)	9(13.8)
0	4(6.2)	16(24.6)		2(3.1)	11(16.9)

¹3+, ≥ 50%; 2+, ≥ 5% and < 50%; 1+, < 5%; 0, negative;

^bP < 0.01 vs normal tissues;

^dP < 0.01 vs normal tissues.

Table 2 Relationship between MRP8 and MRP14 immunoreac-tivity and clinicopathologic factors. (Chi-square Fisher exact test)

	Case Number (n)	MRP8 (+)	P value	MRP14 (+)	P value
Age (yr)
<= 57	35	25	NS	27	NS
> 57	30	21		25
Gender
Male	46	34	NS	37	NS
Female	19	11		13
Differentiation
Well	30	29	< 0.001b	30	< 0.001b
Moderately	23	16		20
Poorly	12	4		4

^bP < 0.001 between MRP8 and MRP14 expression and histologi-cal grade, respectively.