Basic Research
Copyright ©The Author(s) 2004.
World J Gastroenterol. Mar 15, 2004; 10(6): 881-884
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.881
Table 1 Relative frequency of K-ras mutation in ductal lesions with pancreatic diseases
Ductal lesionnK-ras(-)K-ras(+)Positivepercentage (%)
Pancreatic ductal2451979.2
adenocarcinoma
Peritumoral ductal19151473.6
atypical hyperplasia
Peritumoral ductal58382034.5
hyperplasia
Normal duct at the tumor161600
free resection margin
Chronic pancreatitis2416833.3
Normal pancreas7700
Table 2 K-ras mutation pattern of ductal lesions and the cor-responding primary pancreatic carcinoma
Ductal lesionNucleotide sequenceof K-ras12 codon
GATGTTCGT
Pancreatic ductal adenocarcinoma847
Peritumoral ductal atypical hyperplasia723
Peritumoral ductal hyperplasia1037
Chronic pancreatitis422
Table 3 Relationship between K-ras gene mutation and location, histologicalal grade and clinical stage of pancreatic carcinomas
Pathologic factornPositive rate (%)
Tumor location
Head1855.6
Tail/Corpus666.7
Histological grade
G1666. 7
G21050
G3862.5
Clinical stage
I1100
II366.7
III966.7
IV1145.5
Table 4 Clinical and morphologic data on 24 patients with chronic pancteatitis
K-ras positive cases (n = 8)K-ras negative cases (n = 16)
Mean age of patients (yrs)39.9 ± 15.5(19 - 68)51 ± 14.9(23 - 67)
Gender ratio (M:F)6:210:6
Mean duration of CP (yrs)6.7 ± 3.2(2 - 27)5.7 ± 4.5(3 - 25)
Mass-CP of pancreatic head5 cases10 cases
Weight loss (> 10 kg)3 cases7 cases
Diabetes (insulin dependent)4 cases7 cases
Nicotine(> 20 cigarettes/day, > 5 yrs)5 cases8 cases